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The Use of Liprotides To Stabilize and Transport Hydrophobic Molecules

机译：使用Liprootides稳定和运输疏水分子

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摘要

Recently, it has been shown that different complexes consisting of protein and fatty acids, which we call liprotides, have common functional and structural features. Liprotides can transfer their fatty acid content to membranes, highlighting the potential to incorporate other small molecules and help transfer them to membranes. In this study, this potential was explored with regard to the poorly water-soluble vitamin E compound alpha-tocopherol (Toc). Uptake into liprotides increased Toc solubility and chemical stability. The liprotide-Toc complexes retained the characteristic liprotide structure with a core of fatty acid surrounded by protein. Toc and fatty acid could be transferred to artificial vesicles upon being incorporated into the liprotide complex. Extending this work, we found that free tryptophan and the vitamin A precursor retinaldehyde could also be incorporated in the liprotides; however, other small molecules failed to be taken up, and we conclude that successful incorporation requires a hydrophobic terminal moiety that can be accommodated within the micelle interior of the liprotides. Nevertheless, our work suggests that liprotides are able to stabilize and transport a number of otherwise insoluble small molecules with significant potential health benefits.
机译：最近，已经表明，由蛋白质和脂肪酸组成的不同复合物，我们称之为脂质剂，具有共同的功能性和结构特征。 Liprootides可以将其脂肪酸含量转移到膜上，突出掺入其他小分子的可能性并有助于将它们转移到膜上。在这项研究中，探讨了这种潜在的水溶性维生素E复合α-生育酚（TOC）。吸收脂肪糖苷的增长溶解度和化学稳定性增加。 Liprootide-TOC复合物保留了具有由蛋白质包围的脂肪酸的核心的特征性脂蛋白结构。在掺入脂质化合物中时，可以将TOC和脂肪酸转移到人造囊泡。延长这项工作，我们发现提供免费色氨酸和维生素A ind体转基因醛也可以纳入Liprootides;然而，其他小分子未被溶解，我们得出结论，成功的掺入需要疏水末端部分，该部分可以容纳在脂质胶质剂的胶束内部内。然而，我们的作品表明，Liprootides能够稳定和运送许多其他不溶性的小分子，具有显着的潜在健康益处。

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  • 来源
    《Biochemistry》 |2015年第31期|共9页
  • 作者

    Pedersen Jannik N.; Pedersen Jan S.; Otzen Daniel E.;

  • 作者单位

    Aarhus Univ Dept Mol Biol &

    Genet Interdisciplinary Nanosci Ctr iNANO DK-8000 Aarhus C Denmark;

    Aarhus Univ Dept Chem DK-8000 Aarhus C Denmark;

    Aarhus Univ Dept Mol Biol &

    Genet Interdisciplinary Nanosci Ctr iNANO DK-8000 Aarhus C Denmark;

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  • 正文语种 eng
  • 中图分类 生物化学;
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