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首页> 外文期刊>American journal of industrial medicine >Increase in airway hyperresponsiveness among workers exposed to methylene diphenyldiisocyanate compared to workers exposed to toluene diisocyanate at a petrochemical plant in Korea.
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Increase in airway hyperresponsiveness among workers exposed to methylene diphenyldiisocyanate compared to workers exposed to toluene diisocyanate at a petrochemical plant in Korea.

机译：与韩国一家石化厂的甲苯二异氰酸酯工人相比，接触二苯基二异氰酸甲酯的工人呼吸道反应过度增加。

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BACKGROUND: The purpose of this study was to investigate the prevalence of airway hyperresponsiveness induced by methylene diphenyldiisocyanate (MDI) and toluene diisocyanate (TDI) at a petrochemical industry complex in Korea. METHODS: Questionnaires, allergic skin test, and nonspecific airway hyperresponsiveness (AHR) were studied in 64 exposed workers and 27 control subjects. Questionnaires included questions about symptoms of cough, wheezing, chest tightness, dyspnea, rhinorrhea, sneezing, itching, stuffiness, tearing, urticaria, sore throat, and exacerbating time. Methacholine challenge tests were done. Bronchial responsiveness (BRindex) defined as log (% fall in FEV(1))/log (last concentration of methacholine +10). RESULTS: Prevalence of AHR (PC20 FEV(1) < 16.0 mg/mL of methacholine) was higher in MDI-exposed workers than in TDI-exposed workers [4/20 (20%) vs. 2/42 (4.7%), P<0.05]. Twenty-three workers (36%) of all subjects had respiratory symptoms. MDI-exposed workers, in comparison with control subjects, had higher BRindex (0.73+/-0.04 vs. 0.62+/-0.02, P<0.05). Workers exposed to TDI or MDI who had respiratory symptoms (n = 23), in comparison to workers exposed to TDI or MDI without respiratory symptoms (n = 41), had significantly higher BRindex (0.82+/-0.06 vs. 0.60+/-0.02, P<0.05). FEV(1) was significantly negatively correlated with BRindex (r = -0.253, P<0.05). BRindex was not correlated with atopy, smoking status, and exposure duration. CONCLUSIONS: These findings suggest that workers exposed to MDI are at a higher risk of asthma in comparison with TDI-exposed workers and control subjects at a petrochemical plant in Korea. Copyright 2000 Wiley-Liss, Inc.
机译：背景：这项研究的目的是调查在韩国的一家石化工业园区中由亚甲基二苯基二异氰酸酯（MDI）和甲苯二异氰酸酯（TDI）引起的气道高反应性的患病率。方法：调查问卷，过敏性皮肤试验和非特异性气道高反应性（AHR）在64名暴露工人和27名对照受试者中进行。问卷包括关于咳嗽，喘息，胸闷，呼吸困难，鼻漏，打喷嚏，瘙痒，闷闷不乐，流泪，荨麻疹，喉咙痛和恶化时间的症状。进行了甲胆碱激发试验。支气管反应性（BRindex）定义为log（FEV（1）下降百分比）/ log（乙酰甲胆碱的最新浓度+10）。结果：暴露于MDI的工人的AHR（PC20 FEV（1）<16.0 mg / mL乙酰甲胆碱）的发生率高于暴露于TDI的工人[4/20（20％）比2/42（4.7％）， P ＜0.05]。所有受试者中有23名工人（36％）有呼吸道症状。与对照组相比，暴露于MDI的工人具有更高的BR指数（0.73 +/- 0.04对0.62 +/- 0.02，P <0.05）。暴露于TDI或MDI且有呼吸道症状的工人（n = 23）与暴露于TDI或MDI且无呼吸道症状的工人（n = 41）相比，BRindex显着更高（0.82 +/- 0.06 vs. 0.60 +/- 0.02，P <0.05）。 FEV（1）与BRindex显着负相关（r = -0.253，P <0.05）。 BRindex与特应性，吸烟状态和暴露时间无关。结论：这些发现表明，与暴露于MDI的工人相比，在韩国一家石化厂暴露于MDI的工人和对照组的人患哮喘的风险更高。版权所有2000 Wiley-Liss，Inc.

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