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首页> 外文期刊>Bioorganic and medicinal chemistry >Needle in a haystack: Antibacterial activity-guided fractionation of a potato wound tissue extract
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Needle in a haystack: Antibacterial activity-guided fractionation of a potato wound tissue extract

机译：针在大海捞针中：抗菌活性引导的马铃薯伤口组织提取物分级

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摘要

Erwinia carotovora is a major cause of potato tuber infection, which results in disastrous failures of this important food crop. There is currently no effective antibiotic treatment against E. carotovora. Recently we reported antibacterial assays of wound tissue extracts from four potato cultivars that exhibit a gradient of russeting character, finding the highest potency against this pathogen for a polar extract from the tissue formed immediately after wounding by an Atlantic cultivar. In the current investigation, antibacterial activity-guided fractions of this extract were analyzed by liquid chromatography-mass spectrometry (LC-MS) utilizing a quadrupole-time-of-flight (QTOF) mass spectrometer. The most active chemical compounds identified against E. carotovora were: 6-O-nonyl glucitol, Lyratol C, n-[2-(4-Hydroxyphenyl)] ethyldecanamide, alpha-chaconine and alpha-solanine. Interactions among the three compounds, ferulic acid, feruloyl putrescine, and alpha-chaconine, representing metabolite classes upregulated during initial stages of wound healing, were also evaluated, offering possible explanations for the burst in antibacterial activity after tuber wounding and a chemical rationale for the temporal resistance phenomenon.
机译：Erwinia Carotovora是马铃薯块茎感染的主要原因，导致这一重要食品作物的灾难性失败。目前没有针对E. Carotovora的有效抗生素治疗。最近，我们报道了来自四个马铃薯品种的伤口组织提取物的抗菌测定，其表现出象征性的梯度，从大西洋品种伤害后立即形成的组织中，对该病原体的效力最高。在目前的研究中，通过使用四极 - 飞行时间（QTOF）质谱仪通过液相色谱 - 质谱（LC-MS）分析该提取物的抗菌活性引导级分。对E. Carotovora鉴定的最活跃的化合物是：6-O-壬基葡糖醇，Lyratol C，N- [2-（4-羟基苯基）]乙醛丹酰胺，α-链酰胺和α-烯胺。还评估了三种化合物，阿魏甲酸，Foruloyl Putrescine和Alpha-Chaconine中的相互作用，代表伤口愈合初始阶段的代谢物类，在块茎伤害后的抗菌活性和化学理性的抗菌活性中发出可能的解释颞抵抗现象。

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