A strategic approach to the synthesis of ferrocene appended chalcone linked triazole allied organosilatranes: Antibacterial, antifungal, antiparasitic and antioxidant studies

Gurjaspreet Singh; Aanchal Arora; Pooja Kalra; Indresh Kumar Maurya; Cristobal Espinosa Ruizc; M. Angeles Estebanc; Shweta Sinha; Kapil Goyal; Rakesh Sehgal

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A strategic approach to the synthesis of ferrocene appended chalcone linked triazole allied organosilatranes: Antibacterial, antifungal, antiparasitic and antioxidant studies

机译：合成二茂铁附加的Chalcone联系三唑胺酰胺有机硅烷的战略方法：抗菌，抗真菌，抗贫化和抗氧化研究

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A series of ferrocene appended chalcone allied triazole coupled organosilatranes (FCTSa7–FCTSa12) were synthesised with the aim of amalgamating the pharmacological action of the constituting moieties into a single molecular scaffold. All the synthesised silatranes were well characterized by various spectroscopic techniques like IR,1H NMR,13C NMR and elemental analysis. Organosilatranes were then evaluated for their biological alacrity against bacterial and fungal strains compared with the standard drugs Rifampicin and Amphotericin B respectively. The ferrocene conjugates were found to be only moderately effective against the tested microbes. However, the organosilatranes conceded excellent efficacy against parasiteG. lambliawith FCTSa11arraying the leading results. On the other hand against another parasiteT. vaginalis, FCTSa8has emerged as an outstanding composite. Further, Total Antioxidant Assay (TAA) with 2,2′-azino-bis-3-(ethylbenzothiazoline-6-sulphonic acid) revealed FCTSa10to be the best claimant for radical scavenging activity. Along these lines, introducing some different substituents in the synthesised hybrids may act as a useful strategy for increasing the biological profile of the drugs.

机译：一系列的二氧化烯附加的Chalcone亚军三唑偶联有机硅烷（FCTSA7-FCTSA12）被合成，目的是融合构成部分的药理学作用进入单个分子支架。所有合成的硅丙烷均采用IR，1H NMR，13C NMR和元素分析等各种光谱技术表征。然后评估有机硅烷与分别与标准药物利福平和两性霉素B相比的细菌和真菌菌株的生物高分子。发现二茂茂缀合物仅对测试的微生物适度有效。然而，有机硅丙烷对寄生虫的优异疗效得到了极佳的疗效。 Lambliawith fctsa11array领先的结果。另一方面对抗另一个寄生虫。阴道，FCTSA8哈斯作为一个优秀的复合材料。此外，具有2,2'-氮杂-PIS-3-（乙基异噻唑啉-6-磺酸）的总抗氧化剂测定（TAA）显示FCTSA10是激进清除活性的最佳索赔剂。沿着这些线，在合成的杂种中引入一些不同的取代基可以充当增加药物生物学轮廓的有用策略。

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来源
《Bioorganic and medicinal chemistry》 |2019年第1期|共8页
作者
Gurjaspreet Singh; Aanchal Arora; Pooja Kalra; Indresh Kumar Maurya; Cristobal Espinosa Ruizc; M. Angeles Estebanc; Shweta Sinha; Kapil Goyal; Rakesh Sehgal;
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作者单位

Department of Chemistry and Centre of Advanced Studies Panjab University;

Department of Chemistry Khalsa College for Women;

Department of Chemistry and Centre of Advanced Studies Panjab University;

Department of Microbial Biotechnology Panjab University;

Fish Innate Immune System Group Department of Cell Biology and Histology Faculty of Biology;

Fish Innate Immune System Group Department of Cell Biology and Histology Faculty of Biology;

Department of Medical Parasitology Post Graduate Institute of Medical Education and Research;

Department of Medical Parasitology Post Graduate Institute of Medical Education and Research;

Department of Medical Parasitology Post Graduate Institute of Medical Education and Research;

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正文语种 eng
中图分类药学;
关键词
Ferrocene; Chalcone; Silatrane; Antimicrobial activity; Antiparasitic activity; Antioxidant activity;

机译：二茂铁;Chalcone;Silatrane;抗菌活性;抗贫酸活性;抗氧化活性;

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1. A strategic approach to the synthesis of ferrocene appended chalcone linked triazole allied organosilatranes: Antibacterial, antifungal, antiparasitic and antioxidant studies [J] . Gurjaspreet Singh, Aanchal Arora, Pooja Kalra, Bioorganic and medicinal chemistry . 2019,第1期

机译：合成二茂铁附加的Chalcone联系三唑胺酰胺有机硅烷的战略方法：抗菌，抗真菌，抗贫化和抗氧化研究
2. Heteroaryl chalcone allied triazole conjugated organosilatranes: synthesis, spectral analysis, antimicrobial screening, photophysical and theoretical investigations [J] . Gurjaspreet Singh, Aanchal Arora, Sunita Rani, RSC Advances . 2016,第85期

机译：杂芳基Cholcone亚胆三唑共轭有机硅烷：合成，光谱分析，抗微生物筛查，光物理和理论研究
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4. Synthesis, antioxidant and antibacterial activities of 3-nitrophenyl ferrocene [C] . S Benabdesselam, H Izza, T Lanez International Conference on Functional Materials and Chemical Engineering . 2018

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A strategic approach to the synthesis of ferrocene appended chalcone linked triazole allied organosilatranes: Antibacterial, antifungal, antiparasitic and antioxidant studies

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