Novel phospholipid analogues of pan-PPAR activator tetradecylthioacetic acid are more PPARalpha selective.

Rajender; Muller M; Skorve

首页> 外文期刊>Bioorganic and Medicinal Chemistry Letters >Novel phospholipid analogues of pan-PPAR activator tetradecylthioacetic acid are more PPARalpha selective.

【24h】

Novel phospholipid analogues of pan-PPAR activator tetradecylthioacetic acid are more PPARalpha selective.

机译：Pan-PPAR活化剂十四乙酰硫代乙酸的新型磷脂类似物更抗抗抗氨抗性。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Tetradecylthioacetic acid (TTA) is a modified fatty acid that appears to improve insulin sensitivity, lower blood lipid levels, enhance fatty acid oxidation and promote anti-inflammatory action in vivo, through mechanisms partly dependent upon peroxisome proliferator-activated receptors (PPARs). In order to improve the biological efficacy of TTA as a PPAR agonist, two novel phospholipid analogue lyso tetradecylthioacetyl-L-alpha-phosphatidylcholine and di-tetradecylthioacetyl-L-alpha-phosphatidylglycerol have been developed. Here we report on the syntheses of these novel phospholipids and their relative potential to act as PPAR agonists in vitro, in comparison to TTA and other positive controls.

机译：十四烷基硫酸（TTA）是一种改性脂肪酸，其似乎改善胰岛素敏感性，降低血脂水平，增强脂肪酸氧化和促进体内抗炎作用，通过部分依赖于过氧化物体增殖物激活的受体（PPAR）。为了提高TTA作为PPAR激动剂的生物学效果，已经开发出两种新型磷脂类似物溶胶四乙酰基-1-磷脂酰胆碱和二十四烷基硫代乙酰基-1-磷脂酰甘油。在这里，我们报道了与TTA和其他阳性对照相比，这些新型磷脂和它们作为PPAR激动剂充当PPAR激动剂的相对潜力。

著录项

来源
《Bioorganic and Medicinal Chemistry Letters》 |2010年第3期|共4页
作者
Rajender; Muller M; Skorve;
展开▼
作者单位

Department of Chemistry Imperial College Genetic Therapies Centre Imperial College London London SW7 2AZ UK.;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;生物化学;
关键词

相似文献

外文文献
中文文献
专利

1. Novel phospholipid analogues of pan-PPAR activator tetradecylthioacetic acid are more PPARalpha selective. [J] . Rajender, Muller M, Skorve Bioorganic and Medicinal Chemistry Letters . 2010,第3期

机译：Pan-PPAR活化剂十四乙酰硫代乙酸的新型磷脂类似物更抗抗抗氨抗性。
2. Protein kinase A activators and the pan-PPAR agonist tetradecylthioacetic acid elicit synergistic anti-leukaemic effects in AML through CREB. [J] . Erikstein BS, McCormack E, Tronstad K Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis . 2010,第1期

机译：蛋白激酶A激活剂和泛PPAR激动剂十四烷基硫代乙酸通过CREB在AML中引起协同抗白血病作用。
3. Modulation of rat liver apolipoprotein gene expression and serum lipid levels by tetradecylthioacetic acid (TTA) via PPARalpha activation. [J] . Raspe E, Madsen L, Lefebvre AM, Journal of Lipid Research . 1999,第11期

机译：十四烷基硫代乙酸（TTA）通过PPARalpha激活对大鼠肝脏载脂蛋白基因表达和血清脂质水平的调节。
4. INCORPORATION AND WASH-OUT OF CONJUNGATED LINOLEIC ACID (CLA) AND TETRADECYLTHIOACETIC ACID (TTA) IN MUSCLE OF MARKET SIZED SALMON [C] . B. Ruyter, J.V. Jacobsen, J. Skorve, International Conference of the European Aquaculture Society . 2004

机译：在市场尺寸三文鱼的肌肉中掺入和洗涤缀合的亚油酸（CLA）和四乙酰硫代乙酸（TTA）
5. Post-Translational Regulation of FAS-Mediated PPARalpha Activation. [D] . Jensen-Urstad, Anne Patricia Louise. 2013

机译：FAS介导的PPARalpha激活的翻译后调控。
6. Long-term treatment with the pan-PPAR agonist tetradecylthioacetic acid or fish oil is associated with increased cardiac content of n-3 fatty acids in rat [O] . Elin Strand, Bodil Bjorndal, Ottar Nygard, 1993

机译：泛PPAR激动剂十四烷基硫代乙酸或鱼油的长期治疗与大鼠n-3脂肪酸心脏含量增加有关
7. Induction of mitochondrial biogenesis and respiration is associated with mTOR regulation in hepatocytes of rats treated with the pan-PPAR activator tetradecylthioacetic acid (TTA) [O] . Hagland, Hanne, Hodneland, Linn I., Burri, Lena, 2013

机译：诱导线粒体生物发生和呼吸与pan-ppaR活化剂十四烷基硫代乙酸（TTa）处理的大鼠肝细胞中的mTOR调节有关
8. Bile Acids and Lipid Metabolism Ii. Essential Role of Bile Acids in Bile Phospholipid Excretion [R] . Entenman, C., Holloway, R. J., Albright, M. L., 1968

机译：胆汁酸和脂质代谢Ii。胆汁酸在胆汁磷脂排泄中的重要作用

Novel phospholipid analogues of pan-PPAR activator tetradecylthioacetic acid are more PPARalpha selective.

摘要

著录项

相似文献

相关主题

期刊订阅