Regioselective one pot synthesis of 3,3'-diindolylethylene derivatives and study of their cytotoxic activity.

Mandal M; Kumar D; Roy R; Sen R; Das P; Chatterjee M; Jaisankar P

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Regioselective one pot synthesis of 3,3'-diindolylethylene derivatives and study of their cytotoxic activity.

机译：地区1罐合成3,3'-二氯乙烯衍生物及其细胞毒性活性研究。

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摘要

2,2'-Diphenyl-3,3'-diindolylethylene (DPDIE) derivatives 3a-g were regioselectively prepared in one pot from indoles 1a-g in the presence of Lewis acids and were subsequently evaluated for cytotoxic activity against human leukemic cell lines, U937 and K562. The most potent compound 3g exhibited IC(50) of 13.0-17.0 muM.

机译：2,2'-二苯基-3,3'-二甲基乙烯（DPDIE）衍生物3a-g在路易斯酸存在下从吲哚1a-g的一个池中置于一个罐中，随后对人白血病细胞系评估细胞毒性活性， U937和K562。最有效的化合物3G表现出IC（50）的13.0-17.0米。

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《Bioorganic and Medicinal Chemistry Letters》 |2011年第10期|共4页
作者
Mandal M; Kumar D; Roy R; Sen R; Das P; Chatterjee M; Jaisankar P;
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Department of Chemistry Indian Institute of Chemical Biology (Unit of C.S.I.R) 4 Raja S.C. Mullick Road Jadavpur Kolkata 700 032 India.;

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正文语种 eng
中图分类药学;
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1. Regioselective one pot synthesis of 3,3'-diindolylethylene derivatives and study of their cytotoxic activity. [J] . Mandal M, Kumar D, Roy R, Bioorganic and Medicinal Chemistry Letters . 2011,第10期

机译：地区1罐合成3,3'-二氯乙烯衍生物及其细胞毒性活性研究。
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Regioselective one pot synthesis of 3,3'-diindolylethylene derivatives and study of their cytotoxic activity.

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