SPION-Smac mimetic nano-conjugates: Putative pro-apoptotic agents in oncology

SeneciP.; RizziM.; BallabioL.; LecisD.; ContiA.; CarraraC.; LicandroE.

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SPION-Smac mimetic nano-conjugates: Putative pro-apoptotic agents in oncology

机译：Spion-SMAC模拟纳米缀合物：肿瘤学中推定的促凋亡剂

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摘要

Non-covalent (NP-1/3) and covalent (NP-A-1/3) pro-apoptotic SPION-Smac mimetic nano-conjugates antitumor agents are reported. The solution synthesis of key Smac mimetics, their support onto SPIONs through non-covalent adsorption (NP-1/3) or APTES-mediated covalent binding (NP-A-1/3), the analytical characterization of SPION-Smac mimetic conjugates, their target affinity in cell-free assays, and their cytotoxicity against tumor cells are thoroughly described.

机译：报道了非共价（NP-1/3）和共价（NP-A-1/3）促凋亡Spion-SMAC模拟纳米缀合物抗肿瘤剂。通过非共价吸附（NP-1/3）或Aptes介导的共价结合（NP-A-1/3），它们通过非共价吸附（NP-A-1/3），它们的散壳的溶液合成，它们的支撑栓塞（NP-A-1/3）。彻底描述了它们在无细胞测定中的目标亲和力，以及它们对肿瘤细胞的细胞毒性进行彻底描述。

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来源
《Bioorganic and Medicinal Chemistry Letters》 |2014年第10期|共5页
作者
SeneciP.; RizziM.; BallabioL.; LecisD.; ContiA.; CarraraC.; LicandroE.;
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作者单位

Università Degli Studi di Milano Dipartimento di Chimica Via Golgi 19 I-20133 Milan Italy;

Università Degli Studi di Milano Dipartimento di Chimica Via Golgi 19 I-20133 Milan Italy;

Università Degli Studi di Milano Dipartimento di Chimica Via Golgi 19 I-20133 Milan Italy;

Fondazione IRCCS Istituto Nazionale Dei Tumori Dipartimento di Oncologia Sperimentale e Medicina;

Fondazione IRCCS Istituto Nazionale Dei Tumori Dipartimento di Oncologia Sperimentale e Medicina;

Università Degli Studi di Milano Dipartimento di Chimica Via Golgi 19 I-20133 Milan Italy;

Università Degli Studi di Milano Dipartimento di Chimica Via Golgi 19 I-20133 Milan Italy;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Oncology; Peptidomimetics; Pro-apoptotics; Smac mimetics; SPION nanoparticles;

机译：肿瘤学;拟肌瘤;Pro-poptotics;SMAC模拟物;Spion纳米粒子;

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专利

1. SPION-Smac mimetic nano-conjugates: Putative pro-apoptotic agents in oncology [J] . SeneciP., RizziM., BallabioL., Bioorganic and Medicinal Chemistry Letters . 2014,第10期

机译：Spion-SMAC模拟纳米缀合物：肿瘤学中推定的促凋亡剂
2. Dual action Smac mimetics-zinc chelators as pro-apoptotic antitumoral agents [J] . Manzoni Leonardo, Gornati Davide, Manzotti Mattia, Bioorganic and Medicinal Chemistry Letters . 2016,第19期

机译：双重作用的Smac模拟物-锌螯合剂作为促凋亡抗肿瘤药
3. Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis [J] . ManzoniL., BelvisiL., BianchiA., Bioorganic and medicinal chemistry . 2012,第22期

机译：均一和异二聚体Smac模拟物/ IAP抑制剂作为体内活性促凋亡剂。第一部分：综合
4. Study of Morphological Changes in Breast Cancer Cells MCF-7 under the Action of Pro-apoptotic Agents with Laser Modulation Interference Microscope MIM-340 [C] . V. Nebogatikov, A. Nikitiuk, A. Konysheva, International Conference on Physics of Cancer : Interdisciplinary Problems and Clinical Applications . 2017

机译：激光调制干扰显微镜MIM-340在促凋亡剂作用下乳腺癌细胞MCF-7的形态变化研究
5. Cell biology and photochemistry of several photodynamic agents in oncology [D] . Roberts, Walter Gregory 1989

机译：肿瘤学中几种光动力剂的细胞生物学和光化学
6. Cytotoxic and Pro-Apoptotic Effects of a Sub-Toxic Concentration of Fluvastatin on OVCAR3 Ovarian Cancer Cells After its Optimized Formulation to Melittin Nano-Conjugates [O] . Shaimaa M. Badr-Eldin, Nabil A. Alhakamy, Usama A. Fahmy, 2020

机译：氟伐他汀对卵巢3卵巢癌细胞对茂物纳米缀合物的优化制剂后氟伐他汀对卵巢3卵巢癌细胞的细胞毒性和促凋亡作用
7. BH3 profiling discriminates on-target small molecule BH3 mimetics from putative mimetics [O] . Mariana Villalobos-Ortiz, Jeremy Ryan, Thelma N. Mashaka, 2019

机译：BH3分析鉴别目标小分子BH3模拟物从推定的模拟物
8. Role of ei24/PIG8, A Putative Pro-Apoptotic Tumor Suppressor, in Breast Cancer Development and Resistance to Drug Therapy [R] . Spanjaard, R. A. 2005

机译：ei24 / pIG8，一种推定的促凋亡肿瘤抑制因子在乳腺癌发展和抗药物治疗中的作用

SPION-Smac mimetic nano-conjugates: Putative pro-apoptotic agents in oncology

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