Respiratory syncytial virus inhibitors. Part 2: Benzimidazol-2-one derivatives.

Yu KL; Zhang Y; Civiello RL; Trehan AK; Pearce BC; Yin Z; Combrink KD; Gulgeze HB; Wang XA; Kadow KF; Cianci CW; Krystal M; Meanwell NA

首页> 外文期刊>Bioorganic and Medicinal Chemistry Letters >Respiratory syncytial virus inhibitors. Part 2: Benzimidazol-2-one derivatives.

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Respiratory syncytial virus inhibitors. Part 2: Benzimidazol-2-one derivatives.

机译：呼吸道合胞病毒抑制剂。第2部分：Benzimidazol-2-一种衍生物。

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Structure-activity relationships for a series of benzimidazol-2-one-based inhibitors of respiratory syncytial virus are described. These studies focused on structural variation of the benzimidazol-2-one substituent, a vector inaccessible in a series of benzotriazole derivatives on which 2 is based, and revealed a broad tolerance for substituent size and functionality.

机译：描述了一系列苯并咪唑-2-呼吸合胞病毒抑制剂的结构 - 活性关系。这些研究侧重于苯并咪唑-2-一对取代基的结构变化，在其中2的一系列苯并三唑衍生物中可接近的载体，并且揭示了取代基尺寸和官能度的广泛耐受性。

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来源
《Bioorganic and Medicinal Chemistry Letters》 |2004年第5期|共5页
作者
Yu KL; Zhang Y; Civiello RL; Trehan AK; Pearce BC; Yin Z; Combrink KD; Gulgeze HB; Wang XA; Kadow KF; Cianci CW; Krystal M; Meanwell NA;
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Department of Chemistry The Bristol-Myers Squibb Pharmaceutical Research Institute 5 Research Parkway Wallingford CT 06492 USA.;

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原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
inhibitors; derivatives; Respiratory syncytial virus; benzimidazol-2-one;

机译：抑制剂;衍生物;呼吸道合胞病毒;Benzimidazol-2-one;

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专利

1. Respiratory syncytial virus inhibitors. Part 2: Benzimidazol-2-one derivatives. [J] . Yu KL, Zhang Y, Civiello RL, Bioorganic and Medicinal Chemistry Letters . 2004,第5期

机译：呼吸道合胞病毒抑制剂。第2部分：Benzimidazol-2-一种衍生物。
2. Respiratory syncytial virus fusion inhibitors. Part 3: Water-soluble benzimidazol-2-one derivatives with antiviral activity in vivo. [J] . Yu KL, Wang XA, Civiello RL, Bioorganic and Medicinal Chemistry Letters . 2006,第5期

机译：呼吸道合胞病毒融合抑制剂。第3部分：在体内具有抗病毒活性的水溶性苯并咪唑-2-酮衍生物。
3. 1,2,3,9b-Tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 2: Identification of BTA9881 as a preclinical candidate [J] . Bond Silas, Draffan Alistair G., Fenner Jennifer E., Bioorganic and Medicinal Chemistry Letters . 2015,第4期

机译：1,2,3,9b-四氢-5H-咪唑并[2,1-a]异吲哚-5-酮是一类新型的呼吸道合胞病毒（RSV）融合抑制剂。第2部分：确定BTA9881为临床前候选药物
4. A meta-analysis of vaccine effectiveness against bovine herpesvirus, bovine viral diarrhea virus, bovine respiratory syncytial virus, and parainfluenza-type 3 virus in cattle for bovine respiratory di [C] . M.E. Theurer, R.L. Larson, B.J. White Annual Conference of the American^Association^of^Bovine^Practitioners., Conference . 2014

机译：对牛疱疹病毒，牛病毒性腹泻病毒，牛呼吸道和血酸病毒和牛牛呼吸道牛牛牛呼吸道型病毒和Parainfluenza型3病毒的疫苗效果的荟萃分析
5. Immunopathogenesis of bovine respiratory syncytial virus and acute bovine viral diarrhea virus infections in calves [D] . Brodersen, Bruce Wesley. 1996

机译：牛犊牛呼吸道合胞病毒和急性牛病毒性腹泻病毒感染的免疫发病机制
6. Interleukin 1 and interleukin 1 inhibitor production by human macrophages exposed to influenza virus or respiratory syncytial virus. Respiratory syncytial virus is a potent inducer of inhibitor activity [O] . 1986

机译：暴露于流感病毒或呼吸道合胞病毒的人类巨噬细胞产生白介素1和白介素1抑制剂。呼吸道合胞病毒是抑制剂活性的有效诱因
7. Interleukin 1 and interleukin 1 inhibitor production by human macrophages exposed to influenza virus or respiratory syncytial virus. Respiratory syncytial virus is a potent inducer of inhibitor activity [O] . 1986

机译：暴露于流感病毒或呼吸道合胞病毒的人类巨噬细胞产生白介素1和白介素1抑制剂。呼吸道合胞病毒是抑制剂活性的有效诱因
8. Laboratory and Antigenic Studies of Respiratory Syncytial Virus;Evaluation of Respiratory Syncytial, Meningococcal,and Pneumococcal Polysaccharide Vaccines. [R] . forsyth,ben r. phillips,charles a. 1971

机译：呼吸道合胞病毒的实验室和抗原研究;呼吸道合胞体，脑膜炎球菌和肺炎球菌多糖疫苗的评估。

Respiratory syncytial virus inhibitors. Part 2: Benzimidazol-2-one derivatives.

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