Exploiting the furo [2,3-b]pyridine core against multidrug-resistant Mycobacterium tuberculosis

Fumagalli Fernando; Gil de Melo Shaiani Maria; Ribeiro Camila Maringolo; Solcia Mariana Cristina; Pavan Fernando Rogerio; Emery Flavio da Silva

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Exploiting the furo [2,3-b]pyridine core against multidrug-resistant Mycobacterium tuberculosis

机译：利用呋喃[2,3-B]吡啶芯反对多药抗性结核分枝杆菌

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Identification of new antibiotics suitable for the treatment of tuberculosis is required. In addition to selectivity, it is necessary to find new antibiotics that are effective when the tuberculous mycobacteria are resistant to the available therapies. The furo [2,3-b]pyridine core offers potential for this application. Herein, we have described the screening of our in-house library of furopyridines against Mycobacterium tuberculosis and identified a promising selective bioactive compound against different drug-resistant strains of this mycobacteria. The library of compounds was prepared by a C-H amination reaction using mild and metal-free conditions, increasing the available information about the reactivity of furo [2,3-b] pyridine core through this reaction.

机译：需要鉴定适合治疗结核病的新抗生素。除了选择性外，还有必要找到当结核性分枝杆菌对可用疗法抵抗的新抗生素。呋喃[2,3-B]吡啶芯提供了这种应用的潜力。在此，我们已经描述了筛查我们的内部呋骨库对结核分枝杆菌病症，并确定了对该分枝杆菌的不同耐药菌株的有前途的选择性生物活性化合物。通过使用温和和无金属条件，通过C-H胺化反应制备化合物文库，通过该反应增加关于呋喃[2,3-B]吡啶核的反应性的可用信息。

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来源
《Bioorganic and Medicinal Chemistry Letters》 |2019年第8期|共4页
作者
Fumagalli Fernando; Gil de Melo Shaiani Maria; Ribeiro Camila Maringolo; Solcia Mariana Cristina; Pavan Fernando Rogerio; Emery Flavio da Silva;
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作者单位

Univ Sao Paulo FCFRP USP Dept Pharmaceut Sci Sch Pharmaceut Sci Ribeirao Preto Av Cafe S-N;

Univ Sao Paulo FCFRP USP Dept Pharmaceut Sci Sch Pharmaceut Sci Ribeirao Preto Av Cafe S-N;

Sao Paulo State Univ UNESP Dept Biol Sci Sch Pharmaceut Sci Rodovia Araraquara Jau Km01 S-N;

Sao Paulo State Univ UNESP Dept Biol Sci Sch Pharmaceut Sci Rodovia Araraquara Jau Km01 S-N;

Sao Paulo State Univ UNESP Dept Biol Sci Sch Pharmaceut Sci Rodovia Araraquara Jau Km01 S-N;

Sao Paulo State Univ UNESP Dept Biol Sci Sch Pharmaceut Sci Rodovia Araraquara Jau Km01 S-N;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Furopyridine; C-H activation; Tuberculosis; Multidrug-resistant; Antibiotic;

机译：呋骨;C-H活化;结核病;多药抗性;抗生素;

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1. Exploiting the furo [2,3-b]pyridine core against multidrug-resistant Mycobacterium tuberculosis [J] . Fumagalli Fernando, Gil de Melo Shaiani Maria, Ribeiro Camila Maringolo, Bioorganic and Medicinal Chemistry Letters . 2019,第8期

机译：利用呋喃[2,3-B]吡啶芯反对多药抗性结核分枝杆菌
2. Highly electron deficient pyrido[3',2':4,5]furo-[2,3-b]pyridine as a core structure of a triplet host material for high efficiency green phosphorescent organic light-emitting diodes [J] . Chil Won Lee, Jun Yeob Lee Chemical Communications . 2013,第55期

机译：高度缺电子的吡啶并[3'，2'：4,5]呋喃-[2,3-b]吡啶作为三重态基质材料的核心结构，用于高效绿色磷光有机发光二极管
3. Synthesis of new isosteric heterotricyclic derivatives: pyrazolo[3,2-e]pyridine, pyrazolo[3,4-b]pyrrolo[3,2-e]pyridine and furo[2,3-b]pyrazolo[4,3-e]pyridine [J] . Celso de Amorim Camara, Emerson Teixeira da Silva, Eliezer Jesus Barreiro, Heterocyclic communications . 1999,第5期

机译：合成新的等排杂环三环衍生物：吡唑并[3,2-e]吡啶，吡唑并[3,4-b]吡咯并[3,2-e]吡啶和呋喃并[2,3-b]吡唑并[4,3-e] ]吡啶
4. Association between risk assessment scores and lactating cow Mycobacterium avium subsp paratuberculosis ELISA results on dairy farms [C] . L. Pieper, A. Godkin, U. S. Sorge, Annual Conference of the American^Association^of^Bovine^Practitioners. . 2014

机译：风险评估分数与哺乳母牛分枝杆菌之间的关联分枝杆菌分枝杆菌对奶牛场的结果
5. Immune evasion by Mycobacterium tuberculosis: Mycobacterial lipoproteins exploit Toll-like receptor-2 signaling to inhibit class-II MHC antigen processing. [D] . Gehring, Adam J. 2004

机译：结核分枝杆菌的免疫逃逸：分枝杆菌脂蛋白利用Toll样受体2信号转导抑制II类MHC抗原的加工。
6. Multidrug-Resistant Tuberculosis in Panama Is Driven by Clonal Expansion of a Multidrug-Resistant Mycobacterium tuberculosis Strain Related to the KZN Extensively Drug-Resistant M. tuberculosis Strain from South Africa [O] . Fedora Lanzas, Petros C. Karakousis, James C. Sacchettini, 2013

机译：巴拿马的多重耐药结核病是由与南非KZN广泛耐药结核分枝杆菌菌株有关的多重耐药结核分枝杆菌菌株的克隆扩展驱动的
7. Fluorine-containing heterocycles: Part III. Synthesis of some new furo[2,3-b]-, pyrazolo[3,4-b]- and thieno[2,3-b]pyridines with anticipated biological activities [O] . Etify A. Bakhite, Abdu E. Abdel-Rahman, Elham A. Al-Taifi 2014

机译：含氟杂环：第III部分。一些具有预期生物活性的新型呋喃并[2,3-b] - ，吡唑并[3,4-b] - 和噻吩并[2,3-b]吡啶的合成

Exploiting the furo [2,3-b]pyridine core against multidrug-resistant Mycobacterium tuberculosis

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