FR290581, a novel sordarin derivative: synthesis and antifungal activity.

Hanadate T; Tomishima M; Shiraishi N; Tanabe D; Morikawa H; Barrett D; Matsumoto S; Ohtomo K; Maki K

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FR290581, a novel sordarin derivative: synthesis and antifungal activity.

机译：FR290581，一种新型索拉素衍生物：合成和抗真菌活性。

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Sordarin is a unique natural product antifungal agent that is an inhibitor of elongation factor 2. To improve biological activity, we synthesized various compounds by novel modification of the aglycone, sordaricin. As a result, we have discovered the novel sordarin derivative FR290581. This compound exhibited superior activity and a good pharmacokinetic profile, and also displayed good in vivo activity against Candida albicans.

机译：Sordarin是一种独特的天然产物抗真菌剂，是伸长率因子2的抑制剂。为了改善生物活性，通过新的糖苷，令人生畏的新改性合成各种化合物。因此，我们发现了新的Sordarin衍生品FR290581。该化合物表现出优异的活性和良好的药代动力学概况，并且还擅长对念珠菌堪察加人的体内活动。

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《Bioorganic and Medicinal Chemistry Letters》 |2009年第5期|共4页
作者
Hanadate T; Tomishima M; Shiraishi N; Tanabe D; Morikawa H; Barrett D; Matsumoto S; Ohtomo K; Maki K;
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Chemistry Research Labs. Astellas Pharma Inc. 2-1-6 Kashima Yodogawa-ku Osaka 532-8514 Japan.;

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正文语种 eng
中图分类药学;
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1. FR290581, a novel sordarin derivative: synthesis and antifungal activity. [J] . Hanadate T, Tomishima M, Shiraishi N, Bioorganic and Medicinal Chemistry Letters . 2009,第5期

机译：FR290581，一种新型索拉素衍生物：合成和抗真菌活性。
2. Antifungal sordarins. Synthesis and structure-activity relationships of 3',4'-fused dioxolane and dioxane derivatives. [J] . Bueno JoseM, Cuevas JuanC, Fiandor JoseM, Bioorganic and Medicinal Chemistry Letters . 2002,第2期

机译：抗真菌柑桔。 3'，4'-稠合的二氧戊环和二氧六环衍生物的合成及其构效关系。
3. Antifungal Sordarins. Part 4: synthesis and structure--activity relationships of 3',4'-fused alkyl-tetrahydrofuran derivatives. [J] . Bueno JM, Chicharro J, Fiandor JM, Bioorganic and Medicinal Chemistry Letters . 2002,第13期

机译：抗真菌Sordarins。第4部分：3'，4'-稠合烷基-四氢呋喃衍生物的合成与结构-活性关系。
4. Synthesis, characterization of some new l,3-oxazine-4-one derivatives containing 1,3,4-oxadiazole and 1,3,4-thiadiazole moiety with screening some of their biological activity. [C] . Raneen Hashim Rida, Maysoon Tariq Tawfiq International Scientific Conference on Pure Sciences, Brilliant Creativity and Renewed Building . 2019

机译：合成，表征一些含有1,3,4-二唑和1,3,4-噻二唑部分的一些新的L，3-氧嗪-4-一种衍生物，其具有筛选其一些生物活性。
5. Part A: Studies towards total synthesis of an anticancer and antifungal natural product, Pseudolaric acid B; Part B: Synthesis and biological evaluation of Berkeleyamide A and its derivatives [D] . Kulkarni, Swapnil J. 2011

机译：A部分：关于抗癌和抗真菌天然产物假烟酸B的全合成的研究； B部分：伯克利酰胺A及其衍生物的合成和生物学评价
6. Antifungal Activities of R-135853 a Sordarin Derivative in Experimental Candidiasis in Mice [O] . Yasuki Kamai, Masayo Kakuta, Takahiro Shibayama, 2005

机译：Sordarin衍生物R-135853在小鼠念珠菌病中的抗真菌活性
7. Synthesis and Study of 1,2,4-Oxadiazolines derivatives and their Antifungal activity. [O] . Kumar Gaurav Jain, C. P. Singh 2016

机译：1,2,4-二唑胺衍生物及其抗真菌活性的合成及研究。
8. Antifungal, Mosquito Deterrent, and Larvicidal Activity of N- (benzylidene) -3-cyclohexylpropionic Acid Hydrazide Derivatives. [R] . Tabanca, N., Wedge, D. E., Ali, A., 2013

机译：抗真菌剂，灭蚊剂和N-（亚苄基）-3-环己基丙酸酰肼衍生物的杀幼虫活性。

FR290581, a novel sordarin derivative: synthesis and antifungal activity.

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