...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biochemical and Biophysical Research Communications >Preparation of cupric sulfate-based self-emulsifiable nanocomposites and their application to the photothermal therapy of colon adenocarcinoma
【24h】

Preparation of cupric sulfate-based self-emulsifiable nanocomposites and their application to the photothermal therapy of colon adenocarcinoma

机译：基于硫酸铜的自乳化纳米复合材料的制备及其在结肠腺癌的光热疗法中的应用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Nanocomposites (NCs) of cupric sulfate monohydrate (CuSO4) were fabricated by hot-melt extrusion (HME) system equipped with twin screws. Micron-sized bulk powder of CuSO4 was dispersed in the mixture of surfactants (Span 80 and Tween 80) and hydrophilic polymer (polyethylene glycol (PEG) 6000) by HME process. Reduction of surface tension by surfactants and homogeneous dispersion in hydrophilic polymer along with HME technique were introduced to prepare CuSO4 NCs. Dispersion of CuSO4 NCs exhibited approximately 204 nm hydrodynamic size, unimodal size distribution, and positive zeta potential values. Encapsulation of CuSO4 in CuSO4 NCs and the physicochemical interactions between CuSO4 and pharmaceutical excipients were investigated by solid-state studies. Of note, CuSO4 NCs group exhibited higher antiproliferation efficacies, compared with bulk CuSO4, in Caco-2 (human adenocarcinoma) cells at 75 and 100 mu g/mL CuSO4 concentrations (p 0.05). Also, near-infrared laser irradiation to CuSO4 NCs group elevated the antiproliferation efficacies, compared with non-irradiation group, in Caco-2 cells. After intravenous injection in mice, CuSO4 NCs did not show severe in vivo toxicities. Developed CuSO4 NCs can be one of promising candidates of photothermal therapeutic agents for colon cancers. (C) 2018 Elsevier Inc. All rights reserved.
机译：通过配备有双螺钉的热熔挤出（HME）系统制造硫酸硫酸二水合物（CUSO4）的纳米复合材料（NCS）。通过HME方法将CuSO 4的微米尺寸的块状体积粉末分散在表面活性剂（跨度80和吐温80）和亲水性聚合物（聚乙二醇（PEG）6000）的混合物中。引入了表面活性剂的表面张力和亲水聚合物中的均匀分散的表面张力以及HME技术的均匀分散法制备CUSO4 NCS。 CuSO4 NCS的分散表现出约204nm的流体动力学尺寸，单峰尺寸分布和阳性Zeta电位值。通过固态研究研究了CUSO4 NCS中CUSO4和CUSO4和药物赋形剂之间的物理化学相互作用。值得注意的是，与75和100μg/ ml CUSO4浓度的Caco-2（人腺癌）细胞中，CusO4 NCS组表现出更高的抗增殖效率。此外，与CACO-2细胞中的非照射组相比，近红外激光辐射升高了抗增殖效率。在小鼠静脉注射后，Cuso4 NCS在体内毒性没有显示出严重。开发的Cuso4 NCS可以是结肠癌的光热治疗剂的有希望的候选者之一。 （c）2018年Elsevier Inc.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号