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首页> 外文期刊>Biochemical and Biophysical Research Communications >Taste sensitivity to sucrose is lower in outbred Sprague-Dawley phenotypic obesity-prone rats than obesity-resistant rats
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Taste sensitivity to sucrose is lower in outbred Sprague-Dawley phenotypic obesity-prone rats than obesity-resistant rats

机译：对蔗糖的浓度敏感性较低，来自抗肥胖的大鼠的易患Sprague-Dawley表型肥胖肥胖症

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摘要

The purpose of the present study was to better understand the role of sweet taste perception in dietary behavior and body weight in outbred Sprague-Dawley phenotypic obesity-prone and obesity-resistant rats by measuring sucrose taste sensitivity using a conditioned taste aversion paradigm. Rats were given a high fat diet for 2 weeks and were assigned as obesity-prone (P, upper tertile) or obesity-resistant (R, lower tertile) based on weight gain. Each group was then given either chow (C, 10% fat) or the high fat diet (F, 46% fat) for the remainder of the experiment (similar to 18 weeks) such that there were four groups - obesity-prone on chow (C-P), obesity-prone on high fat (H-P), obesity-resistant on chow (C-R), obesity resistant on high fat (H-R). The sucrose sensitivity of phenotypic obesity-prone rats is lower than that of obesity-resistant rats in either H-fed or C-fed group, and all H-fed rats were more sensitivity than their C-fed counterparts (H-P vs. C-P; H-R vs. C-R). Body weight gain and total calories intake of phenotypic obesity-prone rats are more than that of obesity-resistant rats. The results suggest that lower sucrose taste sensitivity may contribute to body weight gain and total calories intake of phenotypic obesity prone rats compared to obesity-resistant rats, and there is correlation between the change in the sweet taste threshold and diet treatment. (C) 2017 Elsevier Inc. All rights reserved.
机译：本研究的目的是通过使用条件味道厌恶范例测量蔗糖味道敏感性，更好地了解甜味的行为和体重在饮食行为和体重方面的作用。大鼠含有高脂饮食2周，并且基于体重增加分配为肥胖易用的（P，上部间隙）或肥胖（r，较低的Tertile）。然后将每组给予剩余的实验（类似于18周）的剩余物（C，10％脂肪）或高脂肪饮食（F，46％脂肪），使得有四组 - 肥胖的倾向于（CP），高脂肪（HP）的肥胖，易于抗肥胖的食物（CR），肥胖对高脂（HR）的抗性。表型肥胖性 - 易于大鼠的蔗糖敏感性低于H型或C喂养组中的肥胖大鼠的血糖敏感性，并且所有H馈除大鼠比其C喂养对应物更敏感（HP与CP; HR与Cr）。体重增加和总卡路里的表型肥胖性易患大鼠的大鼠比肥胖的大鼠更多。结果表明，与肥胖的大鼠相比，较低的蔗糖味道敏感性可能有助于体重增加和表型肥胖症易患大鼠的总卡路里，并且甜味阈值和饮食治疗之间的变化存在相关性。 （c）2017年Elsevier Inc.保留所有权利。

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