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首页> 外文期刊>BioMed research international >The Effect of Thiamine and Thiamine Pyrophosphate on Oxidative Liver Damage Induced in Rats with Cisplatin
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The Effect of Thiamine and Thiamine Pyrophosphate on Oxidative Liver Damage Induced in Rats with Cisplatin

机译：硫胺素和硫胺酮焦磷酸盐对顺铂大鼠诱导氧化肝损伤的影响

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摘要

The aim of this study was to investigate the effect of thiamine and thiamine pyrophosphate (TPP) on oxidative stress induced with cisplatin in liver tissue. Rats were divided into four groups; thiamine group (TG), TPP + cisplatin group (TPG), healthy animal group (HG), and cisplatin only group (CG). Oxidant and antioxidant parameters in liver tissue and AST, ALT, and LDH levels in rat sera were measured in all groups. Malondialdehyde levels in the CG, TG, TPG, and HG groups were 11 ± 1.4, 9 ± 0.5,3 ± 0.5, and 2.2 ± 0.48 ^mol/g protein, respectively. Total glutathione levels were 2 ± 0.7,2.8 ± 0.4,7 ± 0.8, and 9 ± 0.6 nmol/g protein, respectively. Levels of 8-OH/Gua, a product of DNA damage, were 2.7 ± 0.4 pmol/L, 2.5 ± 0.5,1.1 ± 0.3, and 0.9 ± 0.3 pmol/L, respectively. A statistically significant difference was determined in oxidant/antioxidant parameters and AST, ALT, and LDH levels between the TPG and CG groups (P < 0.05). No significant difference was determined between the TG and CG groups (P > 0.05). In conclusion, cisplatin causes oxidative damage in liver tissue. TPP seems to have a preventive effect on oxidative stress in the liver caused by cisplatin.
机译：本研究的目的是探讨硫胺素和硫胺酮焦磷酸盐（TPP）对肝组织中顺铂诱导的氧化应激的影响。大鼠分为四组;硫胺素组（TG），TPP +顺铂组（TPG），健康动物组（HG）和单铂仅组（CG）。在所有基团中测量肝组织和AST，ALT和LDH水平的氧化剂和抗氧化剂参数。 Cg，Tg，Tpg和Hg组中的丙二醛水平分别为11±1.4,9±0.5,3±0.5和2.2±0.48 ^ mol / g蛋白。总谷胱甘肽水平分别为2±0.7,2.8±0.4,7±0.8和9±0.6nmol / g蛋白。 8-OH / GUA的水平，DNA损伤的产物，分别为2.7±0.4pmol / L，2.5±0.5,1.1±0.3和0.9±0.3pmol / L.在TPG和CG基团之间的氧化剂/抗氧化参数和AST，ALT和LDH水平中测定统计学上显着的差异（P <0.05）。在Tg和Cg基团之间没有确定显着差异（p> 0.05）。总之，顺铂导致肝组织中的氧化损伤。 TPP似乎对由顺铂引起的肝脏中的氧化胁迫具有预防作用。

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