...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>BioMed research international >Evaluation of Bone Metabolism in Critically I11 Patients Using CTx and PINP
【24h】

Evaluation of Bone Metabolism in Critically I11 Patients Using CTx and PINP

机译：使用CTX和PINP评估批判性I11患者骨代谢的评估

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background. Prolonged immobilization, nutritional and vitamin D deficiency, and specific drug administration may lead to significant bone resorption. Methods and Patients. We prospectively evaluated critically ill patients admitted to the ICU for at least 10 days. Demographics, APACHE II, SOFA scores, length of stay (LOS), and drug administration were recorded. Blood collections were performed at baseline and on a weekly basis for five consecutive weeks. Serum levels of PINP, β-CTx, iPTH, and 25(OH)vitamin D were measured at each time-point. Results. We enrolled 28 patients of mean age 67.4 ± 2.3 years, mean APACHE II 22.2 ± 0.9, SOFA 10.1 ± 0.6, and LOS 31.6 ± 5.7 days. Nineteen patients were receiving low molecular weight heparin, 17 nor-epinephrine and low dose hydrocortisone, 18 transfusions, and 3 phenytoin. 25(OH)vitamin D serum levels were very low in all patients at all time-points; iPTH serum levels were increased at baseline tending to normalize on 5th week; β-CTx serum levels were significantly increased compared to baseline on 2nd week (peak values), whereas PINP levels were increased significantly after the 4th week. Conclusions. Our data show that critically ill patients had a pattern of hypovitaminosis D, increased iPTH, hypocalcaemia, and BTMs compatible with altered bone metabolism.
机译：背景。长期固定，营养和维生素D缺乏，特定的药物管理可能导致显着的骨吸收。方法和患者。我们预期评估了患有ICU至少10天的患者的重症患者。记录人口统计数据，Apache II，沙发评分，逗留时间（LOS）和药物管理。血液收集在基线上进行，每周一次连续五周进行。在每个时间点测量纤维素PINP，β-CTX，IPTH和25（OH）维生素D的血清水平。结果。我们注册了28名平均年龄67.4±2.3岁，平均Apache II 22.2±0.9，沙发10.1±0.6，以及LOS 31.6±5.7天。 19名患者接受低分子量肝素，17个NOR-肾上腺素和低剂量氢化环，18个输血和3个苯妥英。 25（OH）维生素D在所有时间点的所有患者中都非常低;在基线趋势下，IPTH血清水平升高以在第5周进行正常化;与第2周（峰值）相比，与基线相比，β-CTX血清水平显着增加，而第四周后PinP水平显着增加。结论。我们的数据显示，危重病人患有钙胺素病的模式，IPth，低钙可见和BTMS与改变的骨代谢相容。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号