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首页> 外文期刊>Behavioural Brain Research: An International Journal >Delineation of the working memory profile in female FMR1 premutation carriers: The effect of cognitive load on ocular motor responses
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Delineation of the working memory profile in female FMR1 premutation carriers: The effect of cognitive load on ocular motor responses

机译：划分女性FMR1热销运营商中的工作记忆简介：认知负荷对眼电机响应的影响

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Fragile X mental retardation 1 (FMR1) premutation carriers (PM-carriers) are characterised as having mid-sized expansions of between 55 and 200 CGG repeats in the 5' untranslated region of the FMR1 gene. While there is evidence of executive dysfunction in PM-carriers, few studies have explicitly explored working memory capabilities in female PM-carriers. 14 female PM-carriers and 13 age- and IQ-matched healthy controls completed an ocular motor n-back working memory paradigm. This task examined working memory ability and the effect of measured increases in cognitive load. Female PM-carriers were found to have attenuated working memory capabilities. Increasing the cognitive load did not elicit the expected reciprocal increase in the task errors for female PM-carriers, as it did in controls. However female PM-carriers took longer to respond than controls, regardless of the cognitive load. Further, FMR1 mRNA levels were found to significantly predict PM-carrier response time. Although preliminary, these findings provide further evidence of executive dysfunction, specifically disruption to working memory processes, which were found to be associated with increases in FMR1 mRNA expression in female PM-carriers. With future validation, ocular motor paradigms such as the n-back paradigm will be critical to the development of behavioural biomarkers for identification of PM-carrier cognitive-affective phenotypes. (C) 2015 Elsevier B.V. All rights reserved.
机译：脆弱的X心理延迟1（FMR1）可放访载体（PM-载体）的特征在于在FMR1基因的5'未翻译区域中具有55和200 cgg的中等大小的膨胀。虽然PM - 载体中有行政功能障碍的证据，但很少有研究在女性PM载体中明确探索了工作记忆能力。 14雌性PM - 载体和13岁和IQ匹配的健康控制完成了一个眼电机N背部工作记忆范式。该任务检查了工作记忆能力，测量的认知负荷增加的效果。发现雌性PM载体具有减弱的工作记忆能力。增加认知负荷并未引发女性PM - 载体的任务误差的预期互惠增加，因为它在控制中确实如此。然而，无论认知负荷如何，雌性PM载体比控制更长时间地响应。此外，发现FMR1 mRNA水平显着预测PM载波响应时间。虽然初步，但这些发现提供了行政功能障碍的进一步证据，特别是对工作记忆过程的破坏，这被发现与雌性PM载体中的FMR1 mRNA表达的增加有关。随着未来的验证，眼镜电机范例如N-Back范例将对行为生物标志物的发展至关重要，以鉴定PM载体认知情感表型。 （c）2015 Elsevier B.v.保留所有权利。

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