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首页> 外文期刊>Behavioural Brain Research: An International Journal >Weekday-only chronic oral methylphenidate self-administration in male rats: Reversibility of the behavioral and physiological effects
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Weekday-only chronic oral methylphenidate self-administration in male rats: Reversibility of the behavioral and physiological effects

机译：平日 - 仅慢性口服甲基苯二甲酸甲基苯二甲酸甲基苯二甲酸甲基苯二甲酸甲基苯二甲酸甲基苯二甲酸甲基苯二甲酸甲酯在雄性大鼠中：行为和生理效应的可逆性

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摘要

Methylphenidate (MP) is a commonly prescribed psychostimulant for Attention Deficit Hyperactivity Disorder (ADHD). We recently reported behavioral and developmental effects of chronic MP use in healthy rats. The current study investigated how interrupting chronic MP treatment with weekend abstinence altered the behavioral and physiological consequences of chronic MP treatment, and if prolonged abstinence would reverse the observed effects. Male Sprague Dawley rats were assigned to one of three treatment groups: water (W); low dose (LD) MP; and high dose (HD) MP. For 13 weeks, rats had access to drink from a bottle containing 4 mg/kg MP (LD), 30 mg/kg MP (HD) or water (W) for 1 h, and 10 mg/kg MP (LD), 60 mg/kg MP (HD) or water (W) for the next 7 h, each week day. During weekends, all animals received only water as well as throughout the 5-week-long abstinence phase, which immediately followed the treatment phase. Throughout the treatment phase, regardless of weekend abstinence, chronic MP resulted in significant decreased food and fluid intake and body weight. Also, HD MP exposure resulted in the following behavioral effects: increased open field and circadian locomotor activity; increased latency to immobility and decreased time spent immobile in the forced swim test; increased center activity in the open field and percent of time spent in an open arm of the elevated-plus-maze; and increased social affiliation and memory in the Crawley's three chamber sociability test. During the prolonged (5-week) abstinence phase, all these effects were reversed while HD treated rats increased their fluid intake. These results indicated that intermittent brief abstinence periods (weekend's off-treatment) produced the same behavioral and developmental effects as those previously reported with chronic (7 days/week) MP treatment, but were reversible following a prolonged abstinence period (5 weeks).
机译：甲基酚（MP）是一种通常规定的注意力缺陷多动障碍（ADHD）的精神刺激剂。我们最近报告了慢性MP在健康大鼠中使用的行为和发育效果。目前的研究调查了周末禁欲的慢性MP治疗如何改变了慢性MP治疗的行为和生理后果，如果延长的禁欲会逆转观察到的效果。雄性Sprague Dawley大鼠分配到三个治疗组中的一种：水（W）;低剂量（LD）MP;和高剂量（HD）MP。 13周，大鼠从含有4mg / kg mp（ld），30mg / kg mp（hd）或水（w）的瓶子中获得1小时的瓶子，以及10mg / kg mp（ld），60 Mg / kg MP（HD）或水（W）在每周一天的下半年。在周末，所有动物只接受水以及整个5周长的禁欲阶段，立即遵循治疗阶段。在整个治疗阶段，无论周末禁欲，慢性MP导致食物和液体摄入量和体重显着降低。此外，HD MP曝光导致以下行为效应：开放场和昼夜昼夜运动活动增加;在强制游泳试验中增加了不动的潜伏期，减少了不动的时间;在开放领域的中心活动增加和在高架迷宫的开放式臂上花费的时间百分比;并增加了克劳利三家社社会率测试中的社会联系和记忆。在延长（5周）禁欲期期间，所有这些效果都逆转，而HD处理的大鼠增加流体摄入量。这些结果表明，间歇性短暂的禁欲期（周末的脱机）产生了与先前报道的慢性（7天/周）MP处理的行为和发育效果相同，但在延长的禁欲期（5周）后是可逆的。

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