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首页> 外文期刊>Brain research >LCN2-interacting proteins and their expression patterns in brain tumors
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LCN2-interacting proteins and their expression patterns in brain tumors

机译：LCN2相互作用蛋白及其在脑肿瘤中的表达模式

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摘要

Lipocalin 2 (LCN2) is a member of the lipocalin family. Elevated expression of LCN2 has been observed in many human tumors, suggesting it might be a potential biomarker and/or therapeutic target in malignancies. In this study, we aimed to explore LCN2 interacting proteins through bioinformatics, as well as their biological functions. Protein-protein interaction networks (PPIN) were constructed using LCN2 and its interacting proteins as the core node. These PPINs were scale free biological networks in which LCN2 and its interacting proteins could connect or cross-talk with at least one partner protein. Both functional and KEGG pathway enrichment analyses identified the known and potential biological functions of the PPIN, such as cell migration and cancer-related pathways. Expression levels of the PPIN proteins, as well as their expression correlations, in five types of brain tumor, were analyzed and integrated into the PPIN to illustrate a dynamic change. A significant correlation was found between the survival time of glioblastoma patients and the expression level of 10 genes (LCN2, MMP9, MMP2, PDE4DIP, L2HGDH, HNRNPA1, DDX31, LOXL2, FAM60A and RNF25). Taken together, our results suggest that LCN2 and its interacting proteins are mostly differentially expressed and have a distinguishing co-expression pattern. They might promote proliferation and migration via cell migration signaling and cancer-related pathways. LCN2 and its interacting proteins might be potential biomarkers in glioblastoma.
机译：Lipocalin 2（LCN2）是脂素家族的成员。在许多人类肿瘤中观察到LCN2的升高表达，表明它可能是恶性肿瘤中的潜在生物标志物和/或治疗靶标。在这项研究中，我们旨在探索通过生物信息学的LCN2蛋白质，以及它们的生物学功能。使用LCN2和其相互作用的蛋白质作为核心节点构建蛋白质 - 蛋白质相互作用网络（PPIN）。这些ppins是无规模的生物网络，其中LCN2及其相互作用蛋白可以与至少一种伴侣蛋白连接或交叉谈话。功能和Kegg途径富集分析鉴定了PPIN的已知和潜在的生物学功能，例如细胞迁移和癌症相关的途径。分析PPIN蛋白的表达水平以及五种脑肿瘤中的表达相关性，并集成到PPIN中以说明动态变化。在胶质母细胞瘤患者的存活时间和10个基因的表达水平之间发现了显着的相关性（LCN2，MMP9，MMP2，PDE4DIP，L2HGDH，HNRNPA1，DDX31，LOXL2，FAM60A和RNF25）。我们的结果表明，LCN2及其相互作用蛋白大多数差异表达并具有区别的共表达模式。它们可能通过细胞迁移信号传导和癌症相关途径促进增殖和迁移。 LCN2及其相互作用的蛋白质可能是胶质母细胞瘤中的潜在生物标志物。

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  • 来源
    《Brain research》 |2019年第2019期|共15页
  • 作者

    Du Zepeng; Wu Bingli; Xia Qiaoxi; Zhao Yan; Lin Ling; Cai Zhixiong; Wang Shaohong; Li Enmin; Xu Liyan; Li Yun; Xu Haixiong; Yin Dong;

  • 作者单位

    Sun Yat Sen Univ Sun Yat Sen Mem Hosp Guangdong Prov Key Lab Malignant Tumor Epigenet &

    Shantou Univ Med Coll Dept Biochem &

    Mol Biol Shantou 515041 Guangdong Peoples R China;

    Shantou Univ Med Coll Dept Biochem &

    Mol Biol Shantou 515041 Guangdong Peoples R China;

    Sun Yat Sen Univ Affiliated Shantou Hosp Shantou Cent Hosp Dept Pathol Shantou 515041;

    Shantou Univ Med Coll Dept Biochem &

    Mol Biol Shantou 515041 Guangdong Peoples R China;

    Sun Yat Sen Univ Affiliated Shantou Hosp Shantou Cent Hosp Dept Cardiol Shantou 515041;

    Sun Yat Sen Univ Affiliated Shantou Hosp Shantou Cent Hosp Dept Pathol Shantou 515041;

    Shantou Univ Med Coll Dept Biochem &

    Mol Biol Shantou 515041 Guangdong Peoples R China;

    Shantou Univ Med Coll Inst Oncol Pathol Shantou 515041 Guangdong Peoples R China;

    Sun Yat Sen Univ Sun Yat Sen Mem Hosp Guangdong Prov Key Lab Malignant Tumor Epigenet &

    Sun Yat Sen Univ Affiliated Shantou Hosp Shantou Cent Hosp Dept Neurosurg Shantou 515041;

    Sun Yat Sen Univ Sun Yat Sen Mem Hosp Guangdong Prov Key Lab Malignant Tumor Epigenet &

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学;
  • 关键词

    LCN2; Protein-protein interaction network; Dynamic change; Functional enrichment;

    机译：LCN2;蛋白质 - 蛋白质相互作用网络;动态变化;功能丰富;

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