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首页> 外文期刊>Brain research >Relationship of alpha-MSH and AgRP axons to the perikarya of melanocortin-4 receptor neurons
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Relationship of alpha-MSH and AgRP axons to the perikarya of melanocortin-4 receptor neurons

机译：α-MSH和AGRP轴突的关系与Melanocortin-4受体神经元的Perikarya

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The central melanocortin system is composed of neurons that express either the proopiomelanocortin (POMC) or the agouti-related protein (AgRP). POMC is cleaved in bioactive peptides, including the alpha-melanocyte-stimulating hormone (alpha-MSH). alpha-MSH activates the melanocortin-4 receptor (MC4R) inducing satiety, whereas AgRP acts as an inverse agonist of MC4R. However, only limited information is available regarding possible area-specific differences in the interaction between alpha-MSH and AgRP terminals on MC4R-expressing cells. Therefore, the objective of the present study was to compare the distribution pattern of alpha-MSH and AgRP terminals on the perikarya of MC4R-expressing neurons. We performed a triple-label immunofluorescence reaction in brain series of MC4R-reporter mice to visualize MC4R-expressing neurons together with AgRP and a-MSH terminals. POMC and AgRP neurons project to areas that contain MC4R-expressing cells, although several brain nuclei exhibit AgRP and alpha-MSH terminals, but they do no express MC4R, while other brain areas contain MC4R-expressing cells and receive no apparent innervation of AgRP and POMC neurons. AgRP terminals make more presumptive appositions than a-MSH on the soma of MC4R-expressing neurons of the medial preoptic area and paraventricular nucleus of the hypothalamus (Pa). Additionally, a higher percentage of MC4R cells receive at least one presumptive apposition from AgRP terminals in the median preoptic nucleus and Pa, compared to alpha-MSH appositions. Thus, our study revealed area-specific differences in the interaction between alpha-MSH and AgRP terminals and the soma of MC4R-expressing neurons. These findings provide new insights about the relationship between first- and second-order neurons of the central melanocortin system.
机译：中央素质素系统由神经元组成，可表达ProopioMelanocortin（POMC）或agouti相关蛋白（AGRP）。 POMC在生物活性肽中切割，包括α-黑素细胞刺激激素（α-MSH）。 α-MSH激活Melanocortin-4受体（MC4R）诱导饱腹感，而AgrP则作为MC4R的逆激动剂。然而，只有有限的信息是关于MC4R表达细胞上alpha-MSH和Agrp终端之间的相互作用的特定区域特定差异。因此，本研究的目的是将α-MSH和AGRP末端的分布模式进行比较在MC4R表达神经元的Perikarya上。我们在脑系列MC4R报告小鼠中进行了三重标签免疫荧光反应，以与AGRP和A-MSH终端一起可视化MC4R表达神经元。 POMC和AGRP神经元项目到含有MC4R表达细胞的区域，尽管几种脑核表现出AGRP和α-MSH末端，但它们没有表达MC4R，而其他脑区域含有MC4R表达细胞，并且没有接受AGRP的表观良好的药物POMC神经元。 AgrP终端在MC4R表达神经元的SOMA上进行更多的推定链接性比下丘脑（PA）的MC4R表达神经元的SOMA。另外，与alpha-MSH的邻接相比，较高百分比的MC4R细胞从中位数核心和PA中的Agrp末端接收至少一个预示性宿主。因此，我们的研究揭示了α-MSH和AGRP末端之间的相互作用的区域特异性差异以及表达MC4R的神经元的SOMA。这些发现提供了关于中央黑素激素系统的第一和二阶神经元之间关系的新见解。

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