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首页> 外文期刊>Brain research >A newly identified nociresponsive region in the transitional zone (TZ) in rat sensorimotor cortex
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A newly identified nociresponsive region in the transitional zone (TZ) in rat sensorimotor cortex

机译：大鼠传感器皮质过渡区（TZ）中的新识别的Nociresponsive区域

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The primary somatosensory cortex (S1) comprises a number of functionally distinct regions, reflecting the diversity of somatosensory receptor submodalities innervating the body. In particular, two spatially and functionally distinct nociceptive regions have been described in primate S1 (Vierck et al., 2013; Whitsel et al., 2019). One region is located mostly in Brodmann cytoarchitectonic area 1, where a subset of neurons exhibit functional characteristics associated with myelinated A delta nociceptors and perception of 1st/sharp, discriminative pain. The second region is located at the transition between S1 and primary motor cortex (M1) in area 3a, where neurons exhibit functional characteristics associated with unmyelinated C nociceptors and perception of 2nd/slow, burning pain. To test the hypothesis that in rats the transitional zone (TZ) - which is a dysgranular region at the transition between M1 and S1 - is the functional equivalent of the nociresponsive region of area 3a in primates, extracellular spike discharge activity was recorded from TZ neurons in rats under general isoflurane anesthesia. Thermonoxious stimuli were applied by lowering the contralateral forepaw or hindpaw into a 48-51 degrees C heated water bath for 5-10 s. Neurons in TZ were found to be minimally affected by non-noxious somatosensory stimuli, but highly responsive to thermonoxious skin stimuli in a slow temporal summation manner closely resembling that of nociresponsive neurons in primate area 3a. Selective inactivation of TZ by topical lidocaine application suppressed or delayed the nociceptive withdrawal reflex, suggesting that TZ exerts a tonic facilitatory influence over spinal cord neurons producing this reflex. In conclusion, TZ appears to be a rat homolog of the nociresponsive part of monkey area 3a. A possibility is considered that this region might be primarily engaged in autonomic aspects of nociception.
机译：原发性躯体感染皮层（S1）包括许多功能性不同的区域，反映了在身体的躯体感应受体潜水部的多样性。特别是，在灵长类动物S1中描述了两个空间和功能性不同的伤害区（Vierck等，2013; Whitsel等，2019）。一个地区主要位于Brodmann Cytoarchitionoonic Area 1中，其中神经元的子集表现出与Myelinated A Delta Nociceptors相关的功能特征和1st /夏普，辨别疼痛的感知。第二区域位于区域3A中的S1和初级电动机皮质（M1）之间的过渡，其中神经元表现出与未封口的C伤蛋仔进鼠相关的功能特性和第二/慢，灼热的疼痛的感知。为了测试在大鼠中，过渡区（TZ） - 是在M1和S1之间的转变的过渡区的过渡区 - 是引发物中面积3a的Nociresponsive区的功能等同物，从TZ神经元记录细胞外尖峰放电活性在一般异氟醚麻醉下的大鼠。通过将对侧前爪或后爪降至48-51摄氏度的加热水浴中，施加热毒刺激。发现TZ中的神经元受到非有害的躯体感官刺激，但高度响应于慢速时间总结方式的热毒性皮肤刺激，与灵长类动物区域3a中的Nociresponsive神经元相似。通过局部利用椰子申请选择性灭活TZ抑制或延迟了伤害性戒断反射，表明TZ对脊髓神经元产生滋补促进影响，产生这种反射。总之，TZ似乎是猴子区3A的Nociresponsive部分的大鼠同源物。可能认为该地区可能主要从事伤害伤害的自主语方面。

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