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首页> 外文期刊>Brain research >GABAA receptors in the central nucleus of amygdala (CeA) affect on pain modulation.
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GABAA receptors in the central nucleus of amygdala (CeA) affect on pain modulation.

机译：Amygdala（CEA）中央核中的GABAA受体对疼痛调制影响。

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The central nucleus of the amygdala (CeA), the nociceptive amygdala, serves as the major output nucleus of the amygdala and participates in receiving and processing pain information. Considering the abundance of GABA(A) receptors in the CeA and also the attributed bidirectional roles for GABA in controlling nociception, we examined the effects of bilateral intra-CeA microinjection of a different dose of the GABA(A) receptor agonist, muscimol, and the GABA(A) receptor antagonist, bicuculline, on pain modulation using a tail-flick test. Adult rats were exposed to intra-CeA microinjection of a selective GABA(A) receptor antagonist, bicuculline, (50,100,200,400 ng/side) or a selective GABA(A) receptor agonist, muscimol, (62.5, 125,250,500 ng/side) and subjected to the tail-flick test. Tail-flick latencies were measured every 5 min after drug microinjection for 60 min. Microinjection of bicuculline and muscimol into the CeA increased and decreased tail-flick latency, respectively in a dose-dependent fashion. The hyperalgesic effect of muscimol (500 ng) microinjected into the CeA was attenuated (P<0.001) by a prior microinjection of bicuculline (50 ng) at the same site. The results of the present study showed that locally released GABA in the CeA is involved in pain modulation and suggests the existence of a GABA(A) mediated inhibitory system in the CeA on pain control.
机译：Amygdala（CEA）的中央核（CEA），伤害性杏仁核苷，用作杏仁达拉的主要输出核，并参与接收和加工疼痛信息。考虑到CEA中的GABA（A）受体的丰度以及GABA在控制伤害的GABA的归因化双向作用中，我们研究了双侧CEA微注射对不同剂量的GABA（A）受体激动剂，Muscimol和的影响GABA（A）受体拮抗剂，Biculline，使用尾部轻弹试验进行疼痛调制。将成年大鼠暴露于CEA内部微注射的选择性GABA（A）受体拮抗剂，Biculline，（50,100,200,400ng /侧）或选择性GABA（A）受体激动剂，Muscimol（62.5,125,250,500ng /侧）并进行尾部轻弹测试。在药物微注射后每5分钟测量尾部轻弹延迟60分钟。分别以剂量依赖的方式分别对CEA的黄芩和白谷醇的显微注射增加和减少尾部轻弹延迟。通过同一部位在同一部位在同一部位的先前显微注射（50ng）的先前显微注射，Muscimol（500ng）微观注射到CEA中的痛觉效果。本研究的结果表明，CEA中局部释放的GABA参与疼痛调节，并表明CEA中GABA（A）介导的抑制系统对疼痛控制。

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