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首页> 外文期刊>Brain research >Synergistic effect between citalopram and citicoline on anxiolytic effect in non-sensitized and morphine-sensitized mice: An isobologram analysis
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Synergistic effect between citalopram and citicoline on anxiolytic effect in non-sensitized and morphine-sensitized mice: An isobologram analysis

机译：基于敏化和吗啡致敏小鼠抗焦虑效应的Citalopropran和Citicoline之间的协同作用：异丙醇图分析

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In the present study, the effects of intraperitoneal (i.p.) injections of citalopram and citicoline on morphine-induced anxiolytic effects were investigated in non-sensitized and morphine-sensitized mice using elevated plusmaze (EPM). Subcutaneous (s.c.) administration morphine (5 mg/kg) increased the percentage of open arm time (%OAT, in morphine-sensitized mice), and open arm entries (%OAE, in non-sensitized mice), but not a locomotor activity, indicating an anxiolytic response to morphine. On the other hand, i.p. administration of naloxone decreased %OAT (morphine-sensitized mice), and %OAE (non-sensitized and morphine-sensitized mice), but not a locomotor activity, showing an anxiogenic effect to naloxone. Moreover, i.p.co-administration of citalopram (5 and 10 mg/kg) and citicoline (75 mg/kg) induced the anxiolytic effect. Interestingly, i.p. co-administration of low doses of citalopram (0.5, 1 and 2.5 mg/kg) and citicoline (25 mg/kg) significantly increased %OAT and 0 /0 OAE in non-sensitized as well as %OAT in morphine-sensitized mice, indicating an anxiolytic effect. An isobolographic analysis of data was performed, presenting a synergistic interaction between citalopram and citicoline upon the production of anxiolytic effect in non-sensitized and morphine-sensitized mice. In conclusion, it seems that (1) morphine sensitization affects the anxiety behavior in the EPM, (2) mu-opioid receptors play an important role in morphine anxiolytic effect, (3) citalopram and citicoline induced anti-anxiety effect, (4) a synergistic effect of citalopram and citicoline upon induction of anti-anxiety behavior in non-sensitized and morphine-sensitized mice.
机译：在本研究中，在使用升高的PlusMaze（EPM）的非敏化和吗啡致敏的小鼠中研究了腹膜内（I.P.）intalopram（I.p.）注射对吗啡诱导的抗寒菌效应的影响。皮下（SC）给药吗啡（5mg / kg）增加了开口臂时间（％燕麦，在吗啡致敏的小鼠）的百分比，以及开口臂条目（％OAE，在非敏化小鼠中），但不是运动活性，表明对吗啡的抗焦虑反应。另一方面，I.P.纳洛酮施用％燕麦（吗啡 - 敏化小鼠），％OAE（非致敏和吗啡致敏的小鼠），但不是运动活性，显示对纳洛酮的焦虑作用。此外，I.P.co-施用西酞普兰（5和10mg / kg）和Citicoline（75mg / kg）诱导抗焦虑作用。有趣的是，I.P.将低剂量的西酞普兰（0.5,1和2.5mg / kg）和Citicoline（25mg / kg）的共同给药显着增加，％燕麦和0/0 oae在吗啡致敏小鼠中的非敏化以及％燕麦，表明抗焦虑作用。进行了对数据的异化分析，在非敏化和吗啡致敏的小鼠中施加抗焦虑作用时，在基督普拉氏菌和Citicoline之间表达了协同相互作用。总之，似乎（1）吗啡致敏影响EPM中的焦虑行为，（2）MU-阿片受体在吗啡抗焦虑作用中发挥着重要作用，（3）西酞普兰和Citicoline诱导的抗焦虑效应（4）基于敏化和吗啡致敏小鼠抗焦虑行为诱导抗焦虑行为对抗焦虑行为的协同作用。

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