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The role of oxytocin in alcohol and drug abuse

机译：催产素在酒精和药物滥用中的作用

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摘要

The neuropeptide oxytocin (OXT) plays a key role in adaptive processes associated with reward, tolerance, memory and stress responses. Through interactions with brain reward and stress systems, OXT is known to play a role in several neuropsychiatric disorders, particularly those that involve altered social integration, such as alcohol and drug addiction (Heilig et al., 2016). As such, there is growing interest in the oxytocin system as a potential therapeutic target for the treatment of alcohol and substance use disorders. Accumulating preclinical evidence suggests that administration of OXT influences the development of tolerance, sensitization and withdrawal symptoms, and modulates numerous alcohol/drug-seeking and alcohol/drug-taking behaviors. Further, there is some evidence to suggest that OXT may help to reverse neuroadaptations that occur as a result of chronic alcohol or drug exposure. To date, there have been only a handful of clinical studies conducted in alcohol and drug dependent populations. This review summarizes the preclinical and clinical literature on the effects of OXT administration on alcohol- and drug-related behaviors. In addition, we discuss OXT interactions with the hypothalamic-pituitaryadrenal axis and multiple neurotransmitter systems within addiction circuitry.
机译：神经肽催产素（OXT）在与奖励，公差，记忆和应力响应相关的自适应过程中起关键作用。通过与大脑奖励和压力系统的相互作用，已知OXT在几种神经精神障碍中发挥作用，特别是那些涉及改变社会整合的人，例如酒精和吸毒成瘾（Heilig等，2016）。因此，对催产素系统的兴趣日益增长是治疗酒精和物质使用障碍的潜在治疗靶标。积累的临床前证据表明，OXT的给药影响耐受性，敏化和戒断症状的发展，并调节众多酒精/毒品和酒精/药物的行为。此外，有一些证据表明OXT可能有助于反转由于慢性酒精或药物暴露而发生的神经展望。迄今为止，只有少数少数临床研究在酒精和药物依赖性群体中进行。本综述总结了OXT管理对酒精和药物相关行为的临床和临床文献。此外，我们讨论了与下丘脑 - 垂体轴和多个神经递质系统内的核心相互作用。

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