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Editorial: Mechanistic underpinnings of stem cell therapy for neurological disorders

机译:编辑:神经障碍干细胞疗法的机械底线

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摘要

This special issue entitled "Mechanistic underpinnings of stem cell therapy for neurological disorders" brings together academicians, clinicians and industry partners with vested interest in the safe and effective translation of stem cell-based therapeutics from the laboratory to the clinic. Despite the scientific advances and limited clinical trials of stem cell therapy for neurological disorders, the mechanisms of action remain not fully understood. Here, we provide critical analyses of the therapeutic pathways postulated to mediate stem cell therapy. The views expressed here are based on scientific evidence, but also well-rationalized speculative hypotheses are encouraged in order to guide the field in exploiting the likely responsive pathways, as well as in exploring novel candidate targets which may open venues in optimizing the therapeutic effects of stem cell therapy. In the end, our goal is to coalesce the concerted efforts from stem cell researchers in probing the mechanistic triggers of cell-based treatments towards ensuring the safety and efficacy profiles of stem cell therapy.
机译:这个特别问题题为“神经系统疾病的干细胞疗法机械疗效”致力于院长,临床医生和行业合作伙伴,以既安全有效地将基于实验室的干细胞的治疗方法归属于诊所。尽管科学的进展和神经系统疾病干细胞疗法的临床试验有限,但行动的机制仍然不完全理解。在这里,我们提供假定的治疗途径以介导干细胞疗法的关键分析。这里表达的意见是基于科学证据,也鼓励合理化的投机假设,以引导领域利用可能的响应途径,以及探索可能在优化场地开放场地的新型候选目标干细胞疗法。最终,我们的目标是将干细胞研究人员从干细胞研究人员施加协调努力,探讨细胞的治疗方法朝向确保干细胞疗法的安全性和疗效谱的疗效触发。

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    《Brain research》 |2020年第2020期|共3页
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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学;
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