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首页> 外文期刊>Animal Science Journal >Reduction of allergic symptoms in NC/Jic Jcl mice fed a diet containing casein phosphopeptide preparation, CPP-III
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Reduction of allergic symptoms in NC/Jic Jcl mice fed a diet containing casein phosphopeptide preparation, CPP-III

机译：饲喂含酪蛋白磷酸肽制剂CPP-III的饮食的NC / Jic Jcl小鼠的过敏症状减轻

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摘要

The effect of a commercially available dietary casein phosphopeptide preparation, CPP-III, consisting mainly of bovine as 2-casein (1-32) and casein (1-28) on the development of allergic symptoms mediated by IgE antibody was investigated in NC/Jic Jclmice. No significant difference was observed in the change in mean bodyweight between mice given a diet of a mixture of ovalbumin and CPP-III (CPP-lll-added diet) and those given a diet of ovalbumin alone (control diet) as a protein source. Total allergic score of five mice given the CPP-lll-added diet was less than half that of those given the control diet for 13 weeks. Levels of intestinal total and ovalbumin-specific immunoglobulin (lg)A were significantly higher in the CPP-lll-added diet group thanin the control diet group, while the serum ovalbumin-specific IgE level was significantly smaller in the former. The production of interleukin (IL)-6 by spleen cells from mice that ingested the CPP-lll-added diet for 13 weeks was obviously higher than that by spleen cells from mice administered the control diet, while the formation of IL-4 by spleen cells from the former mice was significantly lower than that by the latter mouse. These results suggest that the oral ingestion of CPP-III may be beneficial in reducing allergic symptoms mediated by IgE antibody.
机译：在NC / NC中研究了市售的饮食酪蛋白磷酸肽制剂CPP-III，其主要成分为2-酪蛋白（1-32）和酪蛋白（1-28），对IgE抗体介导的过敏症状的发展Jic Jclmice。给予卵清蛋白和CPP-III混合物饮食（添加CPP-III饮食）的小鼠与仅给予卵清蛋白的饮食（对照饮食）作为蛋白质源的小鼠之间的平均体重变化无明显差异。接受CPP-11饮食的五只小鼠的总过敏评分低于接受对照饮食13周的那些的一半。添加CPP-III的饮食组的肠道总卵清蛋白和卵清蛋白特异性免疫球蛋白（IgE）A水平显着高于对照饮食组，而血清卵清蛋白特异性IgE水平则明显低于对照组。摄入CPP-III饮食的小鼠脾细胞产生白细胞介素（IL）-6的量明显高于对照组饮食的小鼠脾细胞产生白细胞介素（IL）-6的量，而通过脾脏饮食形成的IL-4前者的细胞明显低于后者。这些结果表明，口服CPP-III可能有助于减轻IgE抗体介导的过敏症状。

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