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首页> 外文期刊>Cancer: A Journal of the American Cancer Society >A Prospective Study of Cerebral, Frontal Lobe, and Temporal Lobe Volumes and Neuropsychological Performance in Children With Primary Brain Tumors Treated With Cranial Radiation
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A Prospective Study of Cerebral, Frontal Lobe, and Temporal Lobe Volumes and Neuropsychological Performance in Children With Primary Brain Tumors Treated With Cranial Radiation

机译：颅辐射治疗脑肿瘤儿童脑，前叶和颞叶和神经心理学性能的前瞻性研究

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BACKGROUND: Cranial radiation therapy (RT) is an important component in the treatment of pediatric brain tumors. However, it can result in long-term effects on the developing brain. This prospective study assessed the effects of cranial RT on cerebral, frontal lobe, and temporal lobe volumes and their correlation with higher cognitive functioning. METHODS: Ten pediatric patients with primary brain tumors treated with cranial RT and 14 age-and sex-matched healthy children serving as controls were evaluated. Quantitative magnetic resonance imaging and neuropsychological assessments (language, memory, auditory and visual processing, and vocabulary) were performed at the baseline and 6, 15, and 27 months after RT. The effects of age, the time since RT, and the cerebral RT dose on brain volumes and neuropsychological performance were analyzed with linear mixed effects model analyses. RESULTS: Cerebral volume increased significantly with age in both groups (P=.01); this increase in volume was more pronounced in younger children. Vocabulary performance was found to be significantly associated with a greater cerebral volume (P=.05) and a lower RT dose (P=.003). No relation was observed between the RT dose and the cerebral volume. There was no difference in the corresponding neuropsychological tests between the 2 groups. CONCLUSIONS: This prospective study found significant relations among the RT dose, cerebral volumes, and rate of vocabulary development among children receiving RT. The results of this study provide further support for clinical trials aimed at reducing cranial RT doses in the pediatric population. (C) 2016 American Cancer Society.
机译：背景：颅辐射治疗（RT）是治疗小儿脑肿瘤的重要组成部分。然而，它可能导致对发展大脑的长期影响。该前瞻性研究评估了颅rt对脑，额叶和颞叶体积的影响及其与较高认知功能的相关性。方法：评估了用颅RT和14岁和性别匹配的健康儿童治疗的10名小儿脑肿瘤的儿科患者进行了评估。在基线和6,15和27个月后进行定量磁共振成像和神经心理学评估（语言，记忆，听觉和视觉处理和词汇）。用线性混合效应模型分析分析了年龄，自rt的时间和rt的时间，以及脑体积和神经心理学性能的脑力rt剂量。结果：两组年龄的脑体积显着增加（P = .01）;在较年轻的孩子中，体积的增加更加明显。发现词汇表现与更大的脑体积（p = .05）和低温剂量（p = .003）显着相关。 RT剂量和脑体积之间没有观察到任何关系。 2组之间的相应神经心理学测试没有差异。结论：这种前瞻性研究发现了RT剂量，脑体积和接受RT的儿童的词汇发育率之间的显着关系。该研究的结果为旨在减少儿科人群中的脑血管甾体剂量的临床试验提供了进一步的支持。 （c）2016年美国癌症协会。

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