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Cationic Chalcogenoviologen Derivatives for Photodynamic Antimicrobial Therapy and Skin Regeneration

机译:用于光动力学抗菌治疗和皮肤再生的阳离子硫代灭菌剂衍生物

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摘要

A series of water-soluble cationic chalcogenoviologen- based photosensitizers for photodynamic antimicrobial therapy (PDAT) is reported. The Se-containing derivatives (SeMV~(2+)) 5b and 6b showed good antimicrobial activities due to the presence of chalcogen atoms and a cationic scaffold. The former efficiently enhanced the generation of reactive oxygen species (ROS), and the latter facilitated the ROS delivery to bacteria, resulting in their death. Interestingly, alkyl-modified photosensitizers showed higher antimicrobial activities than commonly reported photosensitizers with quaternary ammonium (QA) groups. In particular, the SeMV~(2+) (6b) with excellent antibacterial activities efficiently promoted the healing of infected wounds in mice. Simple yet novel, nontoxic and biocompatible chalcogenoviologens provided a promising strategy to develop new efficient photosensitizers for photodynamic antimicrobial therapy and skin regeneration.
机译:报道了一系列用于光动力抗微生物治疗(PDAT)的水溶性阳离子钠化学生殖器胶质剂。 含Se的衍生物(SEMV〜(2+))5B和6B由于硫致原子和阳离子支架存在而良好的抗微生物活性。 前者有效地增强了活性氧(ROS)的产生,后者促进了对细菌的ROS递送,导致他们死亡。 有趣的是,烷基改性的光敏剂表现出比常规报告的季铵(QA)组的光敏剂更高的抗微生物活性。 特别地,具有优异的抗菌活性的SEMV〜(2+)(6B)有效地促进了小鼠感染伤口的愈合。 简单但新颖的,无毒和生物相容性的胆碱中吞噬症提供了有希望的策略来开发用于光动力抗菌治疗和皮肤再生的新型高效光敏性。

著录项

  • 来源
    《Chemistry: A European journal》 |2019年第59期|共7页
  • 作者单位

    Frontier Institute of Science and Technology State Key Laboratory for Strength and Vibration of Mechanical Structures Xi'an Key Laboratory of Sustainable Energy Materials Chemistry Xi'an Jiaotong University Xi'an Shaanxi Province 710054 (China);

    School of Chemical Engineering and Technology Shaanxi Key Laboratory of Energy Chemical Process Intensification Institute of Polymer Science in Chemical Engineering Xi'an Jiaotong University Xi'an Shaanxi Province 710054 (China);

    Frontier Institute of Science and Technology State Key Laboratory for Strength and Vibration of Mechanical Structures Xi'an Key Laboratory of Sustainable Energy Materials Chemistry Xi'an Jiaotong University Xi'an Shaanxi Province 710054 (China);

    Center for Tissue Engineering School of Stomatology Fourth Military Medical University Xi'an Shaanxi Province 710032 (China);

    Frontier Institute of Science and Technology State Key Laboratory for Strength and Vibration of Mechanical Structures Xi'an Key Laboratory of Sustainable Energy Materials Chemistry Xi'an Jiaotong University Xi'an Shaanxi Province 710054 (China);

    Frontier Institute of Science and Technology State Key Laboratory for Strength and Vibration of Mechanical Structures Xi'an Key Laboratory of Sustainable Energy Materials Chemistry Xi'an Jiaotong University Xi'an Shaanxi Province 710054 (China);

    Frontier Institute of Science and Technology State Key Laboratory for Strength and Vibration of Mechanical Structures Xi'an Key Laboratory of Sustainable Energy Materials Chemistry Xi'an Jiaotong University Xi'an Shaanxi Province 710054 (China);

    Frontier Institute of Science and Technology State Key Laboratory for Strength and Vibration of Mechanical Structures Xi'an Key Laboratory of Sustainable Energy Materials Chemistry Xi'an Jiaotong University Xi'an Shaanxi Province 710054 (China);

    School of Chemical Engineering and Technology Shaanxi Key Laboratory of Energy Chemical Process Intensification Institute of Polymer Science in Chemical Engineering Xi'an Jiaotong University Xi'an Shaanxi Province 710054 (China);

    Frontier Institute of Science and Technology State Key Laboratory for Strength and Vibration of Mechanical Structures Xi'an Key Laboratory of Sustainable Energy Materials Chemistry Xi'an Jiaotong University Xi'an Shaanxi Province 710054 (China);

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 应用化学;
  • 关键词

    antibiotics; cationic chalcogenoviologens; membrane intercalating agents; photodynamic antimicrobial therapy; skin regeneration;

    机译:抗生素;阳离子硫代灭绝噻虫;膜插入剂;光动力抗菌治疗;皮肤再生;

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