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首页> 外文期刊>Chemistry: A European journal >High-Field MRI Contrast Agents and their Synergy with Optical Imaging: the Evolution from Single Molecule Probes towards Nano-architectures
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High-Field MRI Contrast Agents and their Synergy with Optical Imaging: the Evolution from Single Molecule Probes towards Nano-architectures

机译：高场MRI造影剂及其光学成像的协同作用：从单分子探头朝向纳米架构的演变

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摘要

Contrast agents for magnetic resonance imaging have historically been based on paramagnetic metal complexes, particularly Gd~(3+) chelates, which tend to lose their contrast enhancement ability with increasing magnetic field strength. Emerging high-field MRI applications require the development of novel contrast agents that exhibit high relaxation enhancement as a function of magnetic field strength. Paramagnetic ions such as Dy~(3+), Tb~(3+) or Ho~(3+) incorporated into supramolecular or inorganic nano-architectures represent promising platforms for the development of high field MRI contrast agents. Furthermore, such platforms allow facile inclusion of multiple imaging modalities, therapeutic loading, and targeting vectors. This Minireview examines the application of contrast agents for high-field MRI, which range from single molecules to nanoparticles. Approaches to create multimodal agents by combining highfield MRI contrast properties with another imaging modality are also discussed.
机译：磁共振成像的造影剂历来基于顺磁性金属配合物，特别是Gd〜（3+）螯合物，其倾向于随着磁场强度的增加而失去了对比增强能力。新兴的高场MRI应用需要开发具有磁场强度的函数的高弛豫增强的新型造影剂。掺入超分子或无机纳米架构的DY〜（3+），TB〜（3+）或HO〜（3+）等顺磁离子代表了高原MRI造影剂的开发的有希望的平台。此外，这种平台允许体内包含多种成像模态，治疗载荷和靶向载体。该MiniView检测高场MRI对比剂的应用，该造影剂从单分子到纳米颗粒。还讨论了通过将HIGHFIELD MRI对比度与另一种成像模态组合来创建多峰代理的方法。

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