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首页> 外文期刊>Chemistry: A European journal >Highly Efficient Intramolecular Electrochemiluminescence Energy Transfer for Ultrasensitive Bioanalysis of Aflatoxin M1
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Highly Efficient Intramolecular Electrochemiluminescence Energy Transfer for Ultrasensitive Bioanalysis of Aflatoxin M1

机译：高效的分子内电化学发光，用于过敏性生物分析的黄曲霉毒素M1

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摘要

The intermolecular electrochemiluminescence resonance energy transfer (ECL-RET) between luminol and Ru(bpy)_3~(2+) was studied extensively to achieve the sensitive bioanalysis owing to the perfect spectral overlap of the donor and acceptor, but it still suffers from the challenging issue of low energy-transfer efficiency. The intramolecular ECL-RET towards the novel ECL compound containing the donor of luminol and the acceptor of Ru(bpy)_2(mcpbpy)~(2+) (Lum-Ru) was designed and investigated. With the high-efficient ECL-RET in one molecule, the highly intense ECL signal of Lum-Ru was obtained owing to the short path of energy transmission and less energy loss between luminol and Ru(bpy)_2(mcpbpy)~(2+). Lum-Ru was further applied to construct a signal-off electrochemiluminescence (ECL) aptasensor for ultrasensitive detection of a harsh carcinogen of Aflatoxin M1 (AFM1). This sensing platform also provides a significant boost for the trace detection of other biomolecules in clinical analysis.
机译：鲁米诺和ru（BPY）_3〜（2+之间的分子间电化学荧光共振能量转移（ECL-RET）被广泛研究，以实现施主和受体的完美光谱重叠，但仍然存在敏感生物分析，但它仍然存在低能量转移效率的挑战性问题。设计并研究了含有鲁米诺供体和Ru（BPY）_2（MCPBPY）〜（2+）（LUM-RU）的新型ECL-RET朝向含有鲁米诺供体的新ECL化合物（MCPBPY）（LUM-RU）。随着一个分子中的高效ECL-RET，由于能量传播的短路和鲁米诺和ru（BPY）_2（MCPBPY）_2（2+ ）。进一步应用Lum-ru以构建信号 - 关闭电化学荧光（ECL）Aptasensor，用于过敏检测Aflatoxin M1（AFM1）的苛刻致癌物质。该传感平台还为临床分析中的其他生物分子进行了显着的提升。

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  • 来源
    《Chemistry: A European journal》 |2017年第8期|共7页
  • 作者

    Jia-Li Liu; Min Zhao; Ying Zhuo; Ya-Qin Chai; Ruo Yuan;

  • 作者单位

    Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University) Ministry of Education College of Chemistry and Chemical Engineering Southwest University Chongqing 400715 (P. R. China);

    Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University) Ministry of Education College of Chemistry and Chemical Engineering Southwest University Chongqing 400715 (P. R. China);

    Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University) Ministry of Education College of Chemistry and Chemical Engineering Southwest University Chongqing 400715 (P. R. China);

    Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University) Ministry of Education College of Chemistry and Chemical Engineering Southwest University Chongqing 400715 (P. R. China);

    Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University) Ministry of Education College of Chemistry and Chemical Engineering Southwest University Chongqing 400715 (P. R. China);

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 应用化学;
  • 关键词

    Aflatoxin M1; electrochemiluminescence; resonance energy transfer; ruthenium; target-induced circular exponential amplification;

    机译：黄毒素M1;电化学发光;谐振能量转移;钌;目标诱导的循环指数放大;

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