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首页> 外文期刊>Chemistry: A European journal >An Iridium(III) Complex as a Photoactivatable Tool for Oxidation of Amyloidogenic Peptides with Subsequent Modulation of Peptide Aggregation
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An Iridium(III) Complex as a Photoactivatable Tool for Oxidation of Amyloidogenic Peptides with Subsequent Modulation of Peptide Aggregation

机译：铱（III）复合物作为氧化淀粉样蛋白肽的氧化剂，随后调节肽聚集

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摘要

Aggregates of amyloidogenic peptides are involved in the pathogenesis of several degenerative disorders. Herein, an iridium(III) complex, Ir-1, is reported as a chemical tool for oxidizing amyloidogenic peptides upon photoactivation and subsequently modulating their aggregation pathways. Ir-1 was rationally designed based on multiple characteristics, including 1) photoproperties leading to excitation by low-energy radiation; 2) generation of reactive oxygen species responsible for peptide oxidation upon photoactivation under mild conditions; and 3) relatively easy incorporation of a ligand on the Ir~(III) center for specific interactions with amyloidogenic peptides. Biochemical and biophysical investigations illuminate that the oxidation of representative amyloidogenic peptides (i.e., amyloid-β, α-synuclein, and human islet amyloid polypeptide) is promoted by light-activated Ir-1, which alters the conformations and aggregation pathways of the peptides. Additionally, their potential oxidation sites are identified as methionine, histidine, or tyrosine residues. Overall, our studies on Ir-1 demonstrate the feasibility of devising metal complexes as chemical tools suitable for elucidating the nature of amyloidogenic peptides at the molecular level, as well as controlling their aggregation.
机译：淀粉样蛋白肽的聚集涉及几种退行性疾病的发病机制。这里，铱（III）复合物IR-1作为用于氧化淀粉样蛋白肽的化学工具，用于光粘活化并随后调节它们的聚集途径。 IR-1基于多种特征合理设计，包括1）光拷贝，导致低能量辐射激发; 2）在温和条件下，对肽氧化负载的反应性氧的产生; 3）相对容易地掺入IR〜（III）中心的配体，用于与淀粉样蛋白肽的特定相互作用。生物化学和生物物理研究阐明了代表性淀粉样蛋白肽（即淀粉样蛋白-β，α-突触核蛋白和人胰岛淀粉样蛋白多肽）的氧化通过光活化的IR-1促进，这改变了肽的构象和聚集途径。另外，它们的潜在氧化位点被鉴定为甲硫氨酸，组氨酸或酪氨酸残基。总体而言，我们对IR-1的研究证明了设计金属配合物作为适合于阐明分子水平在分子水平的淀粉样蛋白肽的性质的化学工具的可行性，以及控制它们的聚集。

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  • 来源
    《Chemistry: A European journal》 |2017年第7期|共9页
  • 作者

    Juhye Kang; Shin Jung C. Lee; Jung Seung Nam; Hyuck Jin Lee; Myeong- Gyun Kang; Kyle J. Korshavn; Hyun-Tak Kim; Jaeheung Cho; Ayyalusamy Ramamoorthy; Hyun-Woo Rhee; Tae-Hyuk Kwon; Mi Hee Lim;

  • 作者单位

    Department of Chemistry Ulsan National Institute of Science and Technology (UNIST) Ulsan 44919 (Republic of Korea);

    Department of Chemistry Ulsan National Institute of Science and Technology (UNIST) Ulsan 44919 (Republic of Korea);

    Department of Chemistry Ulsan National Institute of Science and Technology (UNIST) Ulsan 44919 (Republic of Korea);

    School of Life Sciences UNIST Ulsan 44919 (Republic of Korea);

    Department of Chemistry Ulsan National Institute of Science and Technology (UNIST) Ulsan 44919 (Republic of Korea);

    Department of Chemistry University of Michigan Ann Arbor MI 48109 (USA);

    Department of Chemistry Ulsan National Institute of Science and Technology (UNIST) Ulsan 44919 (Republic of Korea);

    Department of Emerging Materials Science Daegu Gyeongbuk Institute of Science and Technology (DGIST) Daegu 42988 (Republic of Korea);

    Department of Chemistry University of Michigan Ann Arbor MI 48109 (USA);

    Department of Chemistry Ulsan National Institute of Science and Technology (UNIST) Ulsan 44919 (Republic of Korea);

    Department of Chemistry Ulsan National Institute of Science and Technology (UNIST) Ulsan 44919 (Republic of Korea);

    Department of Chemistry Ulsan National Institute of Science and Technology (UNIST) Ulsan 44919 (Republic of Korea);

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 应用化学;
  • 关键词

    aggregation; iridium; oxidation; peptides; photochemistry;

    机译：聚集;铱;氧化;肽;光化学;

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