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Guanine Can Direct Binding Specificity of Ru-dipyridophenazine (dppz) Complexes to DNA through Steric Effects

机译:鸟嘌呤可以通过空间效应将Ru-Dibyridophenazine(DPPZ)配合物的结合特异性直接结合Ru-Dibyidophenazine(DPPZ)复合物与DNA

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摘要

X-ray crystal structures of three L- [Ru(L)_2dppz]~(2+) complexes (dppz=dipyridophenazine; L= 1,10-phenanthroline (phen), 2,2'-bipyridine (bpy)) bound to d((5BrC)GGC/GCCG) showed the compounds intercalated at a 5'-CG-3' step. The compounds bind through canted intercalation, with the binding angle determined by the guanine NH2 group, in contrast to symmetrical intercalation previously observed at 5'-TA-3' sites. This result suggests that canted intercalation is preferred at 5'-CG-3' sites even though the site itself is symmetrical, and we hypothesise that symmetrical intercalation in a 5'-CG-3' step could give rise to a longer luminescence lifetime than canted intercalation.
机译:三个L- [Ru(l)_2dppz]〜(2+)配合物(DPPZ =双吡啶面包物; L = 1,10-菲咯啉(Phen),2,2'-双吡啶(BPY))结合 D((5BRC)GGC / GCCG)显示化合物在5'-CG-3'步骤中插入。 该化合物通过倾斜插入结合,与鸟嘌呤NH2组确定的结合角度,与在5'-Ta-3'位点之前先前观察到的对称嵌段相反。 该结果表明,即使网站本身是对称的,倾斜插入是优选的,即使网站本身是对称的,并且我们假设5'-CG-3'步骤中的对称嵌入可能导致比较长的发光寿命 倾斜的嵌入。

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  • 来源
    《Chemistry: A European journal》 |2017年第21期|共5页
  • 作者单位

    Department of Chemistry University of Reading Whiteknights Reading RG6 6AD (UK);

    Department of Chemistry University of Reading Whiteknights Reading RG6 6AD (UK);

    Department of Chemistry University of Reading Whiteknights Reading RG6 6AD (UK);

    Department of Chemistry University of Reading Whiteknights Reading RG6 6AD (UK);

    Department of Chemistry and Chemical Engineering Chalmers University of Technology 412-96 Gothenberg (Sweden);

    Department of Chemistry and Chemical Engineering Chalmers University of Technology 412-96 Gothenberg (Sweden);

    Diamond Light Source Harwell Science and Innovation Campus Fermi Avenue Didcot OX11 0QX (UK);

    Diamond Light Source Harwell Science and Innovation Campus Fermi Avenue Didcot OX11 0QX (UK);

    Department of Chemistry University of Reading Whiteknights Reading RG6 6AD (UK);

    Department of Pharmacy University of Reading Whiteknights Reading RG6 6AD (UK);

    Department of Chemistry University of Reading Whiteknights Reading RG6 6AD (UK);

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 应用化学;
  • 关键词

    DNA; DNA structures; nucleic acids; structural biology;

    机译:DNA;DNA结构;核酸;结构生物学;

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