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首页> 外文期刊>Chemistry: A European journal >Constructing Implantable SrTiO_3:Yb,Ho Nanofibers for NIRTriggered and Optically Monitored Chemotherapy
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Constructing Implantable SrTiO_3:Yb,Ho Nanofibers for NIRTriggered and Optically Monitored Chemotherapy

机译：构建植入SRTIO_3：YB，呼吸纳米纤维，用于核触发和光学监测化疗

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摘要

Light-responsive and photoluminescent (PL) drugdelivery platforms have sparked fascinating advancements in personalized tumor chemotherapy due to their unique characteristics in biological imaging and manipulated release kinetics. Herein, implantable Yb~(3+) and Ho~(3+) co-doped strontium titanate (SrTiO_3:Yb,Ho) nanofibers were synthesized and decorated on the surface with polyacrylic acid (PAA) molecules. The preliminary in vitro assay confirmed that this implantable fibrous mesh presented sound cytocompatibility. The PAA surface decoration improved the loading capacity of an anticancer drug (doxorubicin (DOX)) and effectively prevented a daunting burst release in a neutral aqueous environment. Owing to the electrostatic bond between PAA and DOX molecules, low-pH microenvironments and NIR (λ=808 nm) irradiation both induced significantly accelerated DOX release and consequently enhanced the local cancer-cell-killing effect. Additionally, the ratio of green-tored emission (I_(545)/I_(655)) from the SrTiO_3:Yb,Ho-PAA fibers responded effectively to the DOX release progress and dosage due to a fluorescence resonance energy transfer (FRET) effect. This unique characteristic enabled optical monitoring of the delivery progress in a timely manner. These SrTiO_3:Yb,Ho-PAA nanofibers, with precise dual-triggering and optical monitoring of DOX release, are expected to serve as a new implantable drug delivery platform for personalized chemotherapy in the future.
机译：由于生物成像和操纵释放动力学的独特特征，光响应和光致发光（PL）药物交付平台引发了个性化肿瘤化疗的迷人进步。在此，可植入的Yb〜（3+）和HO〜（3+）共掺杂钛酸锶（SRTIO_3：YB，HO）纳米纤维被合成并用聚丙烯酸（PAA）分子在表面上装饰。初步体外测定证实，这种可植入的纤维网眼呈现出声学细胞组合性。 PAA表面装饰改善了抗癌药物的负载能力（多柔比星（DOX）），有效地防止了中性水性环境中的令人生畏的爆发释放。由于PAA和DOX分子之间的静电键，低pH微环境和NIR（λ= 808nm）照射均诱导显着加速的DOX释放，从而提高了局部癌细胞杀伤作用。另外，来自SRTIO_3：Yb的绿色渗发射（I_（545）/ I_（655）的比率，HO-PAA纤维有效地响应DOX释放进展和由于荧光共振能量转移（FRET）效应而进行剂量。这种独特的特征能够及时地使传递进展的光学监测。这些SRTIO_3：YB，HO-PAA纳米纤维，预计将成为未来个性化化疗的新植入药物输送平台。

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  • 来源
    《Chemistry: A European journal》 |2017年第10期|共9页
  • 作者

    Yike Fu; Chao Fang; Zhaohui Ren; Gang Xu; Xiang Li; Gaorong Han;

  • 作者单位

    State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University 38 Zheda Road Hangzhou 310027 (P.R. China);

    State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University 38 Zheda Road Hangzhou 310027 (P.R. China);

    State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University 38 Zheda Road Hangzhou 310027 (P.R. China);

    State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University 38 Zheda Road Hangzhou 310027 (P.R. China);

    State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University 38 Zheda Road Hangzhou 310027 (P.R. China);

    State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University 38 Zheda Road Hangzhou 310027 (P.R. China);

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 应用化学;
  • 关键词

    drug delivery; monitoring; nanostructures; near- IR radiation; pH trigger;

    机译：药物递送;监测;纳米结构;近红外辐射;pH触发;

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