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首页> 外文期刊>Chemistry: A European journal >Platinum Complex Assemblies as Luminescent Probes and Tags for Drugs and Toxins in Water
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Platinum Complex Assemblies as Luminescent Probes and Tags for Drugs and Toxins in Water

机译：铂复合组件作为发光探针和药物和毒素中的标签

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摘要

A reactive phosphorescent probe for aza-heterocyclic drugs and toxins was developed, affording a supramolecular emission-switch-on chemosensor in water. Complex formation of the heterocycles with a platinum(II) precursor proceeds readily at ambient conditions, allowing for facile analyte screening. Fifty-two structurally diverse compounds were tested, out of which 23 pyridines, imidazoles, and triazoles formed strongly emissive complex aggregates. Importantly, they all can be clearly distinguished from each other through a principal component analysis, but often also by simple visual inspection, for example, by their emission color differences (large shifts from blue to red). Also, kinetic reaction profiles and time-resolved emission features can provide valuable information for analyte distinction. The Pt~(II) complexes can be applied as emissive labels for drugs and biomolecules, owing to their advantageous photophysical properties and chemical stability in biological media such as blood.
机译：开发了一种反应性磷光探针，在水中产生了超分子发射开关的化学传感器。用铂（II）前体的复合物形成杂环在环境条件下易于进行，允许容易分析物筛选。测试了五十二种结构各种化合物，其中23个吡啶，咪唑和三唑形成强烈发光的复合物聚集体。重要的是，它们可以通过主成分分析来清楚地区分，但通常也通过简单的目视检查，例如，通过它们的发光颜色差异（从蓝色到红色的大移位）。此外，动力反应谱和时间分离的排放特征可以提供有价值的分析物区别的信息。由于它们在血液中的生物介质中的有利的光学性质和化学稳定性，Pt〜（ii）配合物可以应用于药物和生物分子的发射标记。

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