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首页> 外文期刊>Chemistry of Materials: A Publication of the American Chemistry Society >Peptide-Functionalized Amino Acid-Derived Pseudoprotein-Based Hydrogel with Hemorrhage Control and Antibacterial Activity for Wound Healing
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Peptide-Functionalized Amino Acid-Derived Pseudoprotein-Based Hydrogel with Hemorrhage Control and Antibacterial Activity for Wound Healing

机译：肽 - 官能化氨基酸衍生的伪蛋白水凝胶，具有出血控制和伤口愈合的抗菌活性

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摘要

Developing permanent antibacterial and rapid hemostatic wound dressings with excellent biocompatibility is urgently needed and has always gained great attention. Here, a series of amino acid-derived pseudoprotein consisting of poly (ester amide) (PEA)-based hydrogel dressings and three types of cationic short peptides (RGDK, RRRFK, and RRRFRGDK) are prepared. Compared with the antibacterial segments containing hydrogel scaffolds, the method of peptide modification of surface possesses the minimal usage of antibacterial moiety due to the effective contacting wound spots. Direct peptide RRRFRGDK (P3) conjugation to the hydrogel surface through an amidization reaction can enhance the antibacterial and hemostatic abilities with no or minimal outer appearance and inner morphology damage to the original hydrogels. The P3-functionalized hydrogel (Gel-g-P3) presents excellent water uptake capacity, robust mechanical strength, enzymatic biodegradation, good hemocompatibility, and cytocompatibility. Moreover, the Gel-g-P3 hydrogel has better adhesion capacities of blood cell and platelet and exhibits shorter hemostasis time in the mouse-liver injury model. Finally, the wound healing performance is evaluated in vivo using an infected wound model. The results show that the Gel-g-P3 hydrogel has accelerated the wound healing process, implying that the peptide-functionalized PEA-based hydrogels can be used as hemostasis agents and wound dressings for infected wounds.
机译：迫切需要开发具有优异生物相容性的永久性抗菌和快速止血伤口敷料，并且始终效率受到极大的关注。这里，制备由聚（酯酰胺）（豌豆）的水凝胶敷料和三种类型的阳离子短肽（RGDK，RRRFK和RRRFRGDK）组成的一系列氨基酸衍生的假蛋白。与含有水凝胶支架的抗菌区段相比，由于有效接触伤口斑点，表面的肽改性的方法具有最小的抗菌部分的使用。通过酰胺化反应将与水凝胶表面的直接肽RRRFRGDK（P3）缀合可以增强抗菌和止血能力，没有或最小的外观和原始水凝胶的内部形态损伤。 P3官能化水凝胶（GEL-G-P3）呈现出优异的水吸收能力，稳健的机械强度，酶生物降解，良好的血液相位力和细胞组分。此外，凝胶-G-P3水凝胶具有更好的血细胞和血小板的粘附能力，并且在小鼠肝损伤模型中表现出短的止血时间。最后，使用受感染的伤口模型在体内评估伤口愈合性能。结果表明，凝胶-G-P3水凝胶加速了伤口愈合过程，这意味着肽官能化的豌豆基水凝胶可用作止血剂和伤口敷料的感染伤口。

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    Zhu Jie; Han Hua; Li Faxue; Wang Xueli; Yu Jianyong; Qin Xiaohong; Wu Dequn;

  • 作者单位

    Donghua Univ Minist Educ Key Lab Textile Sci &

    Technol Coll Text Shanghai 201620 Peoples R China;

    Donghua Univ Minist Educ Key Lab Textile Sci &

    Technol Coll Text Shanghai 201620 Peoples R China;

    Donghua Univ Minist Educ Key Lab Textile Sci &

    Technol Coll Text Shanghai 201620 Peoples R China;

    Donghua Univ Innovat Ctr Text Sci &

    Technol Shanghai 201620 Peoples R China;

    Donghua Univ Innovat Ctr Text Sci &

    Technol Shanghai 201620 Peoples R China;

    Donghua Univ Minist Educ Key Lab Textile Sci &

    Technol Coll Text Shanghai 201620 Peoples R China;

    Donghua Univ Minist Educ Key Lab Textile Sci &

    Technol Coll Text Shanghai 201620 Peoples R China;

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  • 正文语种 eng
  • 中图分类 工程材料学;
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