The Local and Systemic Actions of Duloxetine in Allodynia and Hyperalgesia Using a Rat Skin Incision Pain Model

Wang Chi-Fei; Russell Gabriella; Strichartz Gary R.; Wang Ging-Kuo

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The Local and Systemic Actions of Duloxetine in Allodynia and Hyperalgesia Using a Rat Skin Incision Pain Model

机译：使用大鼠皮肤切口疼痛模型对度洛西汀在异常性疼痛和痛觉过敏中的局部和全身作用

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BACKGROUND: Duloxetine is an antidepressant effective for major depressive disorder and also the alleviation of pain for patients with diabetic peripheral neuropathy, chronic musculoskeletal pain, and fibromyalgia. How duloxetine works in pain relief remains unknown. In this study, we address whether duloxetine could act as an analgesic via systemic and local applications.

机译：背景：度洛西汀是一种有效的抗抑郁药，可有效缓解重度抑郁症，并减轻糖尿病性周围神经病变，慢性肌肉骨骼疼痛和纤维肌痛患者的疼痛。度洛西汀如何在缓解疼痛中起作用尚不清楚。在这项研究中，我们研究了度洛西汀是否可以通过全身和局部应用作为镇痛药。

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《Anesthesia and Analgesia: Journal of the International Anesthesia Research Society》 |2015年第2期|共13页
作者
Wang Chi-Fei; Russell Gabriella; Strichartz Gary R.; Wang Ging-Kuo;
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1. The Local and Systemic Actions of Duloxetine in Allodynia and Hyperalgesia Using a Rat Skin Incision Pain Model [J] . Wang Chi-Fei, Russell Gabriella, Strichartz Gary R., Anesthesia and Analgesia: Journal of the International Anesthesia Research Society . 2015,第2期

机译：使用大鼠皮肤切口疼痛模型对度洛西汀在异常性疼痛和痛觉过敏中的局部和全身作用
2. Effect of licofelone against mechanical hyperalgesia and cold allodynia in the rat model of incisional pain. [J] . Vijay P. Singh, Chandrashekhar S. Patil, Shrinivas K. Kulkarni Pharmacological reports: PR . 2005,第3期

机译：立氟酮对大鼠切开痛模型的机械性痛觉过敏和冷异常性疼痛的作用。
3. Experimental incision-induced pain in human skin: effects of systemic lidocaine on flare formation and hyperalgesia. [J] . Kawamata M, Takahashi T, Kozuka Y, Pain. . 2002,第1a2期

机译：实验性切口引起的人皮肤疼痛：全身性利多卡因对耀斑形成和痛觉过敏的影响。
4. Demonstration of Increased Leukocyte-Endothelial Interaction in the Systemic Microcirculation Following Localized Ischemia-Reperfusion, in vivo Microscopy Animal Model [C] . H. Sobral do Rosdrio, C. Saldanha, J. Martins e Silva NATO Advanced Study Institute on Vascular Endothelium : Mechanisms of Cell Signaling . 1999

机译：局部缺血再灌注后全身微循环中的白细胞内皮相互作用增加的证明，体内显微镜动物模型
5. Local and systemic consequences of reducing notch signaling in skin keratinocytes. [D] . Demehri, Shadmehr. 2010

机译：减少皮肤角质形成细胞中Notch信号传导的局部和全身性后果。
6. Effects of pinacidil on changes to the microenvironment around the incision site of a skin/muscle incision and retraction in a rat model of postoperative pain [O] . SU CAO, YINBIN QIN, JUNJIE CHEN, -1

机译：吡那地尔对术后疼痛大鼠模型皮肤肌肉切口和回缩切口部位周围微环境变化的影响
7. Corrigendum to “Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodynia following intraplantar formalin in both male and female mice: The role of TLR4 in the evolution of a persistent pain state” Brain Behav. Immun. 56 (2016) 271–280 [O] . S.A. Woller, S.B. Ravula, F.C. Tucci, 2018

机译：“Systemic Tak-242的静脉预防血清结痛过敏，而不是女性小鼠并阻止血液和雌性小鼠血浆饲养蛋白后的延迟异常性：TLR4在持续疼痛状态的演变中的作用”大脑表现。 Immun。 56（2016）271-280
8. Rat Model of Full Thickness Thermal Injury Characterized by Thermal Hyperalgesia, Mechanical Allodynia, Pronociceptive Peptide Release and Tramadol Analgesia. [R] . Fowler, M., Clifford, J. L., Garza, T. H., 2014

机译：热痛觉过敏，机械性异常性疼痛，前列腺素释放肽和曲马多镇痛的全厚度热损伤大鼠模型。

The Local and Systemic Actions of Duloxetine in Allodynia and Hyperalgesia Using a Rat Skin Incision Pain Model

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