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首页> 外文期刊>Carbon: An International Journal Sponsored by the American Carbon Society >Magnetic and fluorescent carbon nanotubes for dual modal imaging and photothermal and chemo-therapy of cancer cells in living mice
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Magnetic and fluorescent carbon nanotubes for dual modal imaging and photothermal and chemo-therapy of cancer cells in living mice

机译：磁性和荧光碳纳米管用于双模型成像和阴光和化学治疗活小鼠的癌细胞

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摘要

Multi-walled carbon nanotubes (MWCNTs) have drawn increasing attention in biomedical fields because of their unique structures and properties, including good photothermal performance, large surface areas, strong near-infrared (NIR) absorbance, and size stability on the nanoscale. However, big challenge for this platform is to achieve fluorescence/magnetic resonance (MR) imaging and photothermal therapy (PTT) therapy in single nanotube. In this work, Multi-walled carbon nanotubes-magnetofluorescent carbon quantum dots/doxorubicin nanocomposites was prepared. The nanocomposite was then used as carriers for targeted drug transport in cancer therapy. These nanocomposites possess high heat-generating ability, pH and NIR responsive drug delivery, and heat-induced high drug release as well. Experiments in vitro and in vivo show that this platform can deliver anti-cancer drugs to targeted cells, releasing them intracellular upon NIR irradiation, and eliminate tumors effectively through chemo/photothermal synergistic therapeutic effect. Based on the findings of this work, further development of using other CNTs as highly efficient NIR agents can be achieved for vivo tumor imaging and chemo/photothermal synergistic therapeutic. (C) 2017 Elsevier Ltd. All rights reserved.
机译：多壁碳纳米管（MWCNT）由于其独特的结构和性能，包括良好的光热性能，大表面积，近红外（NIR）吸收和纳米级尺寸稳定性，因此在生物医学领域增加了越来越长的碳纳米管然而，该平台的大挑战是在单纳米管中实现荧光/磁共振（MR）成像和光热疗法（PTT）治疗。在这项工作中，制备了多壁碳纳米管 - 磁流荧光碳量子点/多柔比星纳米复合材料。然后将纳米复合物用作癌症治疗中靶向药物转运的载体。这些纳米复合材料具有高发电能力，pH和NIR响应性药物递送，以及热诱导的高药物释放。体外和体内实验表明，该平台可以将抗癌药物提供给靶向细胞，将它们的细胞内释放出来，通过化学/光热协同治疗效果有效地消除肿瘤。基于本作作品的发现，可以实现使用其他CNT作为高效NIR药剂的进一步发展，用于体内肿瘤成像和化疗/光热协同治疗方法。 （c）2017 Elsevier Ltd.保留所有权利。

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