Dual modality photothermal OCT and magnetic resonance imaging with carbon nanotubes

机译：碳纳米管的双模态光热OCT和磁共振成像

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Preclinical molecular imaging of cancer has the potential to increase the understanding of fundamental cancer biology, elucidate mechanisms of cancer treatment resistance, and increase effectiveness of drug candidates. Optical and magnetic resonance imaging contain complementary strengths, suitable for gaining a wealth of knowledge when combined. Here, we demonstrate the inherent contrast sensitivity of single walled carbon nanotubes to absorption based photothermal optical coherence tomography (PT-OCT), and magnetic resonance imaging spin dephasing contrast (T_2). A spectral-domain OCT system was interfaced with an amplitude-modulated (100 Hz) titanium sapphire pump beam for PT-OCT imaging. MRI was performed with a commercial 4.7 T animal scanner. With both imaging tools, contrast agent signal linearity (r~2 > 0.95) and nM sensitivity over background (p < 0.05) was experimentally determined with serially dilute solutions of carbon nanotubes coated in amine-terminated polyethylene glycol. The surface functionalization chemistry for carbon nanotubes is well understood, and molecular targeting has been demonstrated in vitro and in vivo, making carbon nanotubes an attractive agent for molecular imaging in preclinical models. We have demonstrated the initial characterization steps for using carbon nanotubes for multi-modality imaging with PT-OCT and MRI.

机译：癌症的临床前分子影像学有可能增进对基础癌症生物学的了解，阐明癌症治疗耐药性的机制，并提高候选药物的有效性。光学和磁共振成像具有互补的优势，适合结合使用时获得大量知识。在这里，我们证明了单壁碳纳米管对基于吸收的光热光学相干断层扫描（PT-OCT）和磁共振成像自移相移对比度（T_2）的固有对比度敏感性。光谱域OCT系统与调幅（100 Hz）钛蓝宝石泵浦光束对接以进行PT-OCT成像。 MRI用市售的4.7 T动物扫描仪进行。使用这两种成像工具，用涂有胺端基的聚乙二醇的碳纳米管的连续稀释溶液，通过实验确定了对比剂信号线性（r〜2> 0.95）和相对于背景的nM灵敏度（p <0.05）。碳纳米管的表面官能化化学已广为人知，并且已在体外和体内证明了分子靶向性，使碳纳米管成为临床前模型中分子成像的诱人剂。我们已经展示了使用碳纳米管通过PT-OCT和MRI进行多模态成像的初始表征步骤。

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《Reporters, markers, dyes, nanoparticles, and molecular probes for biomedical applications IV》|2012年|p.823310.1-823310.8|共8页
会议地点 San Francisco CA(US)
作者
Jason M. Tucker - Schwartz; Tu Hong; Daniel C. Colvin; Yaqiong Xu; Melissa C. Skala;
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Department of Biomedical Engineering, Vanderbilt University, VU Station B Box 351631, Nashville TN, 37235;

Department of Electrical Engineering and Computer Science, Vanderbilt University, 2301 Vanderbilt Place, Nashville TN, 37235;

Department of Radiology and Radiological Sciences, Vanderbilt University, 1161 21st Ave South, Medical Center North, Nashville TN, 37232;

Department of Electrical Engineering and Computer Science, Vanderbilt University, 2301 Vanderbilt Place, Nashville TN, 37235;

Department of Biomedical Engineering, Vanderbilt University, VU Station B Box 351631, Nashville TN, 37235;

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正文语种 eng
中图分类医用物理学;
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1. Dual-modality photothermal optical coherence tomography and magnetic-resonance imaging of carbon nanotubes [J] . Jason M. Tucker-Schwartz, Tu Hong, Daniel C. Colvin, Optics Letters . 2012,第5期

机译：碳纳米管的双模态光热光学相干层析成像和磁共振成像
2. Magnetic and fluorescent carbon nanotubes for dual modal imaging and photothermal and chemo-therapy of cancer cells in living mice [J] . Zhang Ming, Wang Wentao, Wu Fan, Carbon: An International Journal Sponsored by the American Carbon Society . 2017,第期

机译：磁性和荧光碳纳米管用于双模型成像和阴光和化学治疗活小鼠的癌细胞
3. Magnetofluorescent Fe3O4/carbon quantum dots coated single-walled carbon nanotubes as dual-modal targeted imaging and chemo/photodynamic/photothermal triple-modal therapeutic agents [J] . Zhang Ming, Wang Wentao, Cui Yingjun, Chemical engineering journal . 2018,第期

机译：磁荧光Fe3O4 /碳量子点涂覆单壁碳纳米管，为双型靶向成像和化疗/光动力/光热三重型治疗剂
4. Novel Single Walled Carbon Nanotube Based Magnetic-Fluorescent Nanohybrids as Dual-Modal MRI/Optical Imaging Probes [C] . Bingdi Chen, Tian Zhou, Bo Zhang, International Conference on Manufacturing Science and Engineering . 2012

机译：基于新型单壁碳纳米管的磁性荧光纳米苞剂作为双模态MRI /光学成像探针
5. Improved Interpretation of Brain Anatomical Structures in Magnetic Resonance Imaging Using Information from Multiple Image Modalities [D] . Ghayoor, Ali. 2017

机译：使用来自多个图像模态的信息改进磁共振成像中脑解剖结构的解释
6. Dual Modality Photothermal Optical Coherence Tomography and Magnetic Resonance Imaging of Carbon Nanotubes [O] . Jason M. Tucker – Schwartz, Tu Hong, Daniel C. Colvin, -1

机译：双模态光热光学相干断层扫描和碳纳米管的磁共振成像
7. MODERATED EPOSTERS1385Longitudinal strain assessment in dilated cardiomyopathy patients using a novel accelerated DENSE sequence1407Simultaneous T1 and T2 cardiac quantification with CABIRIA: initial clinical experience1423Head-to-head comparison of acceleration algorithms in 4-dimensional flow CMR1502Left ventricular function and size evaluated by hybrid cardiac positron emission tomography-magnetic resonance: Intraindividual comparison of left ventricular ejection fraction and ventricular volumes derived by two modalities1510Left Atrium assessed by Cardiovascular Magnetic Resonance at 1.5 and 3 Tesla – age and gender effects1514Comparison of Free Breathing Cardiac MRI Radial technique to the Standard Multi breath-hold cine SSFP CMR technique for the assessment of LV Volumes and Function1536Self-navigated free-breathing isotropic 3D whole heart phase sensitive inversion recovery magnetic resonance without navigator for detection of myocardial infarction1547Assessment of Right Ventricular Strain Using Myocardial Deformation Recovery Semi Automated Technique: Initial Experience and Normal Values1586Tissue tracking myocardial deformation analysis and prediction of left ventricular remodeling in acute myocardial infarction1589Investigating strategies for optimal 31P MRS clinical cardiac at 3T: Initial Results1620Quantitative Criteria for the Diagnosis of the Congenital Absence of Pericardium by Cardiac Magnetic Resonance1632Widespread tissue injury during acute myocardial infarction: evidence from advanced CMR relaxometry1322Computed tomography coronary angiography verSus sTRess cArdiac magneTic rEsonance for the manaGement of sYmptomatic revascularized patients: a cost effectiveness study (STRATEGY study)1339Comparison of low- versus high-dose of gadobutrol for late gadolinium enhancement imaging at 1.5 Tesla: a clinical feasibility study1347Multi-parametric Cardiac Magnetic Resonance for Prediction of Cardiac Complications in Thalassemia Intermedia: a Prospective Multicenter Study1461Prognostic value of Cardiovascular Magnetic Resonance derived indexes of myocardial fibrosis in heart transplant recipients1523The role of CMR in the acute phase of hospitalization: changing paradigms1542Preoperative CMR-based score predict ventricular response after surgical left ventricular reconstruction in ischemic heart failure patients1555Excellent response rate to cardiac resynchronization therapy guided with magnetic resonance imaging1626The ECG as a predictor of arrhythmogenic substrate on Cardiac Magnetic Resonance Imaging in patients undergoing ablation for premature ventricular contractions1649Comparison of T1-mapping at 3.0T CMR and angiographic APPROACH score for area at risk assessment in ST-segment elevation myocardial infarction1340Pathological correlates of left bundle branch disease in patients with non-ischemic cardiomyopathy: a cardiovascular magnetic resonance study1342Myocardial remodelling and fibrosis in nonischaemic dilated cardiomyopathy: insights from cardiovascular magnetic resonance1411The association between fibrosis and contractile dysfunction in hypertrophic cardiomyopathy assessed by cardiovascular magnetic resonance1622Persistent myocardial inflammation due to intramyocardial haemorrhage in reperfused STEMI as a precursor to adverse LV remodelling - insights from multi-parametric mapping1566Semiquantitative analysis of low and high b value DWI for detecting myocardial edema in acute myocarditis1567Value of Cardiac MRI In Detecting Coronary Artery Disease In Newly Diagnosed Systolic Dysfunction1570Usefulness of cardiac magnetic resonance in tuberous sclerosis complex1578Papillary muscles offer further insight into hypertrophied hearts: a cardiovascular magnetic resonance study1627Diagnostic and clinical implications of CMR timing (early versus late) in patients with troponin positive acute coronary syndromes and unobstructed coronary arteries: Table 1. [O] . Upasana Tayal, Alexandros Kallifatidis, P. Garg, 2016

机译：在使用新的扩张型心肌病的患者缓和EPOSTERS1385Longitudinal应变评估加速DENSE sequence1407Simultaneous T1和T2与CABIRIA心脏定量：在4维流动的加速算法初始临床experience1423Head对头比较CMR1502Left心室功能和尺寸由混合心脏正电子发射断层摄影术评价 - 磁性共振：由两个modalities1510Left庭派生左室射血分数和心室体积的个体间的比较，在1.5和3特斯拉评估心血管磁共振 - 免费的年龄和性别effects1514Comparison呼吸心脏MRI径向技术标准的多屏气电影SSFP CMR技术的LV卷和Function1536Self-导航自由呼吸各向同性3D整个心脏相位敏感反转恢复磁共振导航仪没有检测右Ventricu心肌infarction1547Assessment的评估拉尔菌株使用心肌变形恢复半自动技术：初步经验和正常Values1586Tissue跟踪心肌变形分析和预测左室重构急性心肌infarction1589Investigating策略优化31P MRS临床心脏在3T：初始Results1620Quantitative标准的先天缺失的诊断心包心脏磁Resonance1632Widespread组织损伤急性心肌梗死时：证据先进CMR relaxometry1322Computed CT冠状动脉成像与压力心脏磁共振对症的管理吻合血管患者：成本效益研究（战略研究）1339Comparison低与高剂量钆布醇在1.5特斯拉晚钆增强成像的临床可行性，在中间型地贫心脏并发症的预测study1347Multi参数心脏核磁共振的前瞻性德穆尔心血管磁共振的ticenter Study1461Prognostic价值衍生心肌纤维化指标在住院的急性期CMR的心脏移植recipients1523The作用：改变基于CMR-paradigms1542Preoperative比分预测缺血性心脏衰竭patients1555Excellent响应速度外科左心室重建心脏再同步化后心室反应治疗与磁共振imaging1626The ECG导引作为心脏磁共振成像致心律失常性基板的在ST段抬高心肌infarction1340Pathological在风险评估经历在3.0T CMR T1映射的室性早搏contractions1649Comparison和血管造影APPROACH分数区域消融患者的预测左束支传导疾病的患者与非缺血性心肌病相关因素：心血管磁共振study1342Myocardial重塑和纤维化nonischaemic扩张型心肌病：在从在由心血管磁性resonance1622Persistent心肌炎症评估肥厚型心肌病的纤维化和收缩功能障碍之间心血管磁性resonance1411The协会由于心肌内出血景点在再灌注STEMI为先导，以不利的LV重塑 - 从低的多参数mapping1566Semiquantitative分析和高的b值DWI的见解为在心脏MRI检测冠状动脉疾病急性myocarditis1567Value在结节性硬化症complex1578Papillary肌肉初诊收缩期Dysfunction1570Usefulness心脏磁共振检测心肌水肿提供进一步的深入了解肥大心脏：心血管磁共振study1627Diagnostic和CMR定时的临床意义（早期与晚）患者肌钙蛋白阳性的急性冠脉综合征和通畅的冠状动脉：表1。

Dual modality photothermal OCT and magnetic resonance imaging with carbon nanotubes

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