MicroRNA-21 Mediates Isoflurane-induced Cardioprotection against Ischemia-Reperfusion Injury via Akt/Nitric Oxide Synthase/Mitochondrial Permeability Transition Pore Pathway

Qiao Shigang; Olson Jessica M.; Paterson Mark; Yan Yasheng; Zaja Ivan; Liu Yanan; Riess Matthias L.; Kersten Judy R.; Liang Mingyu; Warltier David C.; Bosnjak Zeljko J.; Ge Zhi-Dong

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MicroRNA-21 Mediates Isoflurane-induced Cardioprotection against Ischemia-Reperfusion Injury via Akt/Nitric Oxide Synthase/Mitochondrial Permeability Transition Pore Pathway

机译：MicroRNA-21通过Akt /一氧化氮合酶/线粒体通透性过渡孔通路介导异氟烷诱导的抗缺血再灌注损伤的心脏保护作用

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Background: The role of microRNA-21 in isoflurane-induced cardioprotection is unknown. The authors addressed this issue by using microRNA-21 knockout mice and explored the underlying mechanisms.

机译：背景：microRNA-21在异氟烷诱导的心脏保护中的作用尚不清楚。作者通过使用microRNA-21基因敲除小鼠解决了这个问题，并探索了潜在的机制。

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《Anesthesiology》 |2015年第4期|共13页
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Qiao Shigang; Olson Jessica M.; Paterson Mark; Yan Yasheng; Zaja Ivan; Liu Yanan; Riess Matthias L.; Kersten Judy R.; Liang Mingyu; Warltier David C.; Bosnjak Zeljko J.; Ge Zhi-Dong;
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正文语种 eng
中图分类麻醉学;
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1. MicroRNA-21 Mediates Isoflurane-induced Cardioprotection against Ischemia-Reperfusion Injury via Akt/Nitric Oxide Synthase/Mitochondrial Permeability Transition Pore Pathway [J] . Qiao Shigang, Olson Jessica M., Paterson Mark, Anesthesiology . 2015,第4期

机译：MicroRNA-21通过Akt /一氧化氮合酶/线粒体通透性过渡孔通路介导异氟烷诱导的抗缺血再灌注损伤的心脏保护作用
2. Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts [J] . GrossG.J., HsuA., PfeifferA.W., Journal of Molecular and Cellular Cardiology . 2013,第Null期

机译：内皮一氧化氮合酶（eNOS）和线粒体通透性转换孔（MPTP）在环氧二十碳三烯酸（EET）诱导的大鼠完整心肌梗死心肌保护中的作用
3. Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts [J] . GrossG.J., HsuA., PfeifferA.W., Journal of Molecular and Cellular Cardiology . 2013,第Null期

机译：内皮一氧化氮合酶（ENOS）和线粒体渗透率过渡孔（MPTP）在环氧二碳酸（EET）中的作用 - 在完整大鼠心脏中对梗死的心脏保护作用
4. The Activation of Coenzyme Q Biosynthesis and Decreasing the Sensitivity of the Mitochondrial Permeability Transition Pore Opening Provide Cardioprotection against Ischemia-Reperfusion in Old Rats [C] . S.V. CHORNA, N.A. STRUTYNSKA, G.L.VAVILOVA, Advances in biomedical research . 2010

机译：辅酶Q生物合成的激活和线粒体通透性转变孔开口的敏感性降低为老年大鼠缺血再灌注提供了心脏保护。
5. Mitochondrial Calcium Regulation In Cardiac Myocytes: Local Gradients Of Intra-Mitochondrial Calcium, Mitochondrial Calcium Uniporter And Permeability Transition Pore-Mediated Calcium Homeostasis [D] . Lu, Xiyuan. 2015

机译：心肌细胞中的线粒体钙调节：线粒体内钙，线粒体钙单向转运蛋白的局部梯度和通透性转变介导的钙稳态
6. MicroRNA-21 mediates isoflurane-induced cardioprotection against ischemia/reperfusion injury via Aktitric oxide synthase/mitochondrial permeability transition pore pathway [O] . Shigang Qiao, Jessica M. Olson, Mark Paterson, -1

机译：MicroRNA-21通过Akt /一氧化氮合酶/线粒体通透性转变孔通路介导异氟烷诱导的抗缺血/再灌注损伤的心脏保护作用
7. MicroRNA-21 Mediates Isoflurane-induced Cardioprotection against Ischemia–Reperfusion Injury via Akt/Nitric Oxide Synthase/Mitochondrial Permeability Transition Pore Pathway [O] . Shigang Qiao, Jessica M. Olson, Mark Paterson, 2015

机译：MicroRNA-21通过Akt /一氧化氮合酶/线粒体渗透过渡孔隙途径介导异氟烷诱导的心脏保护免受缺血再灌注损伤的缺血再灌注损伤

MicroRNA-21 Mediates Isoflurane-induced Cardioprotection against Ischemia-Reperfusion Injury via Akt/Nitric Oxide Synthase/Mitochondrial Permeability Transition Pore Pathway

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