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首页> 外文期刊>Circulation: An Official Journal of the American Heart Association >Determinants of left ventricular early-diastolic lengthening velocity: independent contributions from left ventricular relaxation, restoring forces, and lengthening load.
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Determinants of left ventricular early-diastolic lengthening velocity: independent contributions from left ventricular relaxation, restoring forces, and lengthening load.

机译：左心室早期舒张延长速度的决定因素：左心室松弛，恢复力和延长载荷的独立贡献。

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BACKGROUND: Peak early-diastolic mitral annulus velocity (e') by tissue Doppler imaging has been introduced as a clinical marker of diastolic function. This study investigates whether lengthening load (early-diastolic load) and restoring forces are determinants of e' in addition to rate of left ventricular (LV) relaxation. METHODS AND RESULTS: In 10 anesthetized dogs, we measured e' by sonomicrometry and tissue Doppler imaging during baseline, volume loading, caval constriction, dobutamine infusion, and occlusion of the left anterior descending coronary artery. Relaxation was measured as the time constant (tau) of LV pressure decay by micromanometer. Lengthening load was measured as LV transmural pressure at mitral valve opening (LVP(MVO)). Restoring forces were quantified by 2 different indices: (1) As the difference between minimum and unstressed LV diameter (Lmin-L0) and (2) as the estimated fully relaxed LV transmural pressure (FRP(Est)) at minimum diameter. In the overall analysis, a strong association was observed between e' and LVP(MVO) (beta=0.49; P<0.001), which indicates an independent effect of lengthening load, as well as between e' and Lmin-L0 (beta=-0.38; P<0.002) and between e' and FRP(Est) (beta=-0.31; P<0.002), consistent with an independent contribution of restoring forces. A direct effect of rate of relaxation on e' was observed in a separate analysis of baseline, dobutamine, and ischemia when postextrasystolic beats were included (beta=-0.06, P<0.01). CONCLUSIONS: The present study indicates that in the nonfailing ventricle, in addition to LV relaxation, restoring forces and lengthening load are important determinants of early-diastolic lengthening velocity.
机译：背景技术：组织多普勒成像的峰值早期舒张分子环速度（E'）作为舒张功能的临床标记。本研究研究了延长载荷（早期舒张载荷）和恢复力是E'除了左心室（LV）弛豫的速率之外的决定因素。方法和结果：在10个麻醉犬，我们测量e'通过基线，体积载荷，穴穴收缩，多巴酚丁胺输注和左前期下降冠状动脉闭塞的典型测量术和组织多普勒成像。通过微距计测量LV压力衰减的时间常数（TAU）。在二尖瓣开口（LVP（MVO））下测量延长负载作为LV透射压力。通过2个不同的指数量化恢复力：（1）作为最小和无关注的LV直径（Lmin-L0）和（2）之间的差异，因为估计的完全松弛的LV透射压力（FRP（EST））最小直径。在整体分析中，在E'和LVP（MVO）（β= 0.49; p <0.001）之间观察到强关节，这表明延长负载的独立效果，以及e'和lmin-l0（beta = -0.38; p <0.002）和e'和frp（est）（beta = -0.31; p <0.002），与恢复力的独立贡献一致。在包括脱右晶搏动时的基线，多巴酚丁胺和缺血的单独分析中，观察到e'e'对E'的直接影响（β= -0.06，p <0.01）。结论：本研究表明，在非造成的心室中，除了LV松弛，恢复力和延长负荷是早期舒张延长速度的重要决定因素。

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