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首页> 外文期刊>Current Biology: CB >Selective Inhibition of Volitional Hand Movements after Stimulation of the Dorsoposterior Parietal Cortex in Humans
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Selective Inhibition of Volitional Hand Movements after Stimulation of the Dorsoposterior Parietal Cortex in Humans

机译：刺激人类背脓性榫胞皮层后的同志手动运动的选择性抑制作用

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摘要

Inhibition is a central component of motor control. Although current models emphasize the involvement of frontal networks [], indirect evidence suggests a potential contribution of the posterior parietal cortex (PPC). This region is active during inhibition of upper-limb movements to undesired targets [], and its stimulation with single magnetic pulses can depress motor-evoked potentials []. Also, it has been speculated that alien hand movements caused by focal parietal lesions reflect a release of inhibition from PPC to M1 []. Considering these observations, we instructed 16 patients undergoing awake brain surgery to perform continuous hand movements while electrical stimulation was applied over PPC. Within a restricted dorsoposterior area, we identified focal sites where stimulation prevented movement initiation and instantly inhibited ongoing responses (which restarted promptly at stimulation offset). Inhibition was selective of the instructed response. It did not affect speech, hand movements passively generated through muscle electrical stimulation, or the ability to initiate spontaneous actions with other body segments (e.g., the feet). When a patient inadvertently performed a bilateral movement, a bilateral inhibition was found. When asked to produce unilateral movements, this patient presented a contralesional but not ipsilateral inhibition. This selectivity contrasted sharply with the unspecific inhibitions reported by previous studies within frontal regions, where speech and all limbs are typically affected (as we here confirm in a subset of patients) []. These results provide direct evidence that a specific area in the dorsoposterior parietal cortex can inhibit volitional upper-limb responses with high selectivity.
机译：抑制是电动机控制的中心部件。虽然目前的模型强调了正面网络的参与[]，间接证据表明后部皮质（PPC）的潜在贡献。该区域在抑制上肢运动期间是有效的，对不期望的靶标[]，并且其用单个磁脉冲的刺激可以抑制电动机诱发的电位[]。此外，已经推测局灶性病变引起的外星手动运动反映了PPC至M1 []的抑制释放。考虑到这些观察结果，我们指示16名患者接受令人醒着的脑部手术，以进行连续的手动运动，而在PPC上施用电刺激。在受限制的背络区域内，我们鉴定了刺激阻止运动启动并立即抑制持续反应的焦点遗址（在刺激抵消时迅速重启）。抑制是对指示的反应选择性。它没有影响言语，通过肌肉电刺激被动地产生的手动运动，或者用其他身体区段启动自发动作的能力（例如，脚）。当患者无意中进行双侧运动时，发现了双侧抑制。当被要求制作单方面的运动时，该患者呈现相对的但不是同侧抑制。这种选择性急剧性地与前部区域内的先前研究报告的未特异性抑制形成对比，其中语音和所有肢体通常受到影响（如我们在此确认患者的子集）[]。这些结果提供了直接证据，即背脓性椎间眼皮层中的特定区域可以抑制具有高选择性的激动式上肢反应。

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