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首页> 外文期刊>Current Biology: CB >A Positive Feedback between Growth and Polarity Provides Directional Persistency and Flexibility to the Process of Tip Growth
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A Positive Feedback between Growth and Polarity Provides Directional Persistency and Flexibility to the Process of Tip Growth

机译：生长和极性之间的积极反馈提供了对尖端生长过程的定向持久性和灵活性

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Polar cell growth is a conserved morphogenetic process needed for survival, mating, and infection []. It typically implicates the assembly and spatial stabilization of a cortical polar domain of the active form of?a small GTPase of the Rho family, such as Cdc42, which promotes cytoskeleton assembly and secretion needed for local surface expansion []. In multiple physiological instances, polarity domains may switch from being spatially unstable, exhibiting a wandering behavior around the cell surface, to being?stable at a fixed cellular location []. Here, we show that the rate of surface growth may be a key determinant in controlling the spatial stability of active Cdc42 domains. Reducing the growth rate of?single rod-shaped fission yeast cells using chemical, genetic, and mechanical means systematically causes polar domains to detach from cell tips and oscillate around the cell surface within minutes. Conversely, an abrupt increase in growth rate improves domain stabilization. A candidate screen identifies vesicular transport along actin cables as an important module mediating this process. Similar behavior observed in distant filamentous fungi suggests that this positive feedback between growth and polarity could represent a basal property of eukaryotic polarization, promoting persistent polar growth as well as growth redirection with respect to the mechanical environment of cells.
机译：极性细胞生长是存活，交配和感染所需的保守的形态发生过程[]。它通常含有rho家族的活性形式的皮质极性结构域的组装和空间稳定性，例如CDC42，其促进局部表面膨胀所需的细胞骨架组件和分泌物[]。在多种生理学实例中，极性畴可以从空间不稳定切换，在细胞表面周围呈现漫长的行为，在固定蜂窝位置进行稳定[]。在这里，我们表明表面生长的速率可以是控制活性CDC42结构域的空间稳定性的关键决定因素。使用化学，遗传和机械方法降低单棒状裂变酵母细胞的生长速率系统地使极性域从细胞尖端脱离，并在几分钟内围绕细胞表面振荡。相反，生长速率的突然增加提高了域稳定化。候选屏幕识别沿着肌动蛋白电缆的紫外线传输，作为调解该过程的重要模块。在远处丝状真菌中观察到的类似行为表明，生长和极性之间的这种阳性反馈可以代表真核偏振的基础特性，促进持续的极性生长以及相对于细胞的机械环境的生长重定向。

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