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首页> 外文期刊>Current Biology: CB >APC/C-Cdh1 Enables Removal of Shugoshin-2 from the Arms of Bivalent Chromosomes by Moderating Cyclin-Dependent Kinase Activity
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APC/C-Cdh1 Enables Removal of Shugoshin-2 from the Arms of Bivalent Chromosomes by Moderating Cyclin-Dependent Kinase Activity

机译：APC / C-CDH1通过调节细胞周期蛋白依赖性激酶活性，可以从二价染色体的臂中移除曲子素-2

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摘要

In mammalian females, germ cells remain arrested as primordial follicles. Resumption of meiosis is heralded by germinal vesicle breakdown, condensation of chromosomes, and their eventual alignment on metaphase plates. At the first meiotic division, anaphase-promoting complex/cyclosome associated with Cdc20 (APC/C-Cdc20) activates separase and thereby destroys cohesion along chromosome arms. Because cohesion around centromeres is protected by shugoshin-2, sister chromatids remain attached through centromeric/pericentromeric cohesin. We show here that, by promoting proteolysis of cyclins and Cdc25B at the germinal vesicle (GV) stage, APC/C associated with the Cdh1 protein (APC/C-Cdh1) delays the increase in Cdk1 activity, leading to germinal vesicle breakdown (GVBD). More surprisingly, by moderating the rate at which Cdk1 is activated following GVBD, APC/C-Cdh1 creates conditions necessary for the removal of shugoshin-2 from chromosome arms by the Aurora B/C kinase, an event crucial for the efficient resolution of chiasmata.
机译：在哺乳动物女性中，生殖细胞仍然被逮捕为原始卵泡。通过发芽囊泡击穿，染色体缩合及其在中期印刷的最终对准，恢复减数分裂。在第一个减数分裂分裂中，促进与CDC20（APC / C-CDC20）相关的复络/环体激活分离酶，从而破坏沿染色体臂的内聚力。因为焦粒子周围的凝聚力由舒霉素-2保护，姐妹染色体保留通过焦化/蠕虫芳烃尼蛋白。在此显示，通过在发芽囊泡（GV）阶段的Cyclins和CDC25b的蛋白水解，与CDH1蛋白（APC / C-CDH1）相关的APC / C延迟CDK1活性的增加，导致生发囊泡击穿（GVBD ）。更令人惊讶的是，通过调节GVBD激活CDK1的速率，APC / C-CDH1产生从Aurora B / C激酶从染色体臂移除曲子素-2所需的条件，这是Chiasmata有效分辨率至关重要的事件。

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  • 来源
    《Current Biology: CB》 |2017年第10期|共20页
  • 作者

    Rattani Ahmed; Mejia Randy Ballesteros; Roberts Katherine; Roig Maurici B.; Godwin Jonathan; Hopkins Michael; Eguren Manuel; Sanchez-Pulido Luis; Okaz Elwy; Ogushi Sugako; Wolna Magda; Metson Jean; Pendas Alberto M.; Malumbres Marcos; Novak Bela; Herbert Mary; Nasmyth Kim;

  • 作者单位

    Univ Oxford Dept Biochem South Parks Rd Oxford OX1 3QU England;

    Newcastle Fertil Ctr Ctr Life Times Sq Newcastle Upon Tyne NE1 4EP Tyne &

    Wear England;

    Univ Oxford Dept Biochem South Parks Rd Oxford OX1 3QU England;

    Univ Oxford Dept Biochem South Parks Rd Oxford OX1 3QU England;

    Univ Oxford Dept Biochem South Parks Rd Oxford OX1 3QU England;

    Univ Oxford Dept Biochem South Parks Rd Oxford OX1 3QU England;

    Spanish Natl Canc Res Ctr CNIO Cell Div &

    Canc Grp Madrid 28029 Spain;

    Univ Edinburgh Inst Genet &

    Mol Med MRC Human Genet Unit Edinburgh EH4 2XU Midlothian Scotland;

    Univ Oxford Dept Biochem South Parks Rd Oxford OX1 3QU England;

    Univ Oxford Dept Biochem South Parks Rd Oxford OX1 3QU England;

    Univ Oxford Dept Biochem South Parks Rd Oxford OX1 3QU England;

    Univ Oxford Dept Biochem South Parks Rd Oxford OX1 3QU England;

    Univ Salamanca CSIC Inst Biol Mol &

    Celular Canc Salamanca Salamanca 37007 Spain;

    Spanish Natl Canc Res Ctr CNIO Cell Div &

    Canc Grp Madrid 28029 Spain;

    Univ Oxford Dept Biochem South Parks Rd Oxford OX1 3QU England;

    Newcastle Fertil Ctr Ctr Life Times Sq Newcastle Upon Tyne NE1 4EP Tyne &

    Wear England;

    Univ Oxford Dept Biochem South Parks Rd Oxford OX1 3QU England;

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  • 正文语种 eng
  • 中图分类 生物科学;
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