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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >Determination of tolerable dose of litchi fruit considering reported hypoglycin A and MCPG contents through biochemical and histopathological evaluations in mice
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Determination of tolerable dose of litchi fruit considering reported hypoglycin A and MCPG contents through biochemical and histopathological evaluations in mice

机译：考虑通过小鼠的生化和组织病理学评估，考虑报告的低遗传蛋白A和MCPG含量的荔枝果实的测定

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摘要

Litchi fruit has recently been reported to be associated with encephalopathy outbreaks in India due to presence of hypoglycaemic phytotoxins, hypoglycin A (HGA) and methylenecyclopropyl-glycine (MCPG). Therefore, a need was felt to determine safe tolerable dose of fruit based upon animal feeding studies. Swiss albino female mice (in each group, n = 6) were fed in both starved and unstarved conditions with maximum possible quantity of litchi pulp within 10 h duration at 2.5 h intervals (total quantity similar to 16 g). This did not result in hypoglycaemia, weight loss or changes in behaviour. Haematology profile, liver and kidney functions remain unchanged. Histopathological analysis of brain, liver and kidney too did not indicate any structural changes. From the reported range of above toxins in litchi pulp the quantity fed corresponds to the cumulative minimum concentration of 2.48 and similar to 9.0 mg/kg body weight of mice for HGA and MCPG respectively, which is lesser than LD50 values of these toxins, i.e. 90-100 mg/kg body weight reported in rat. Thus based upon equivalent dose-quantity conversion, approx. 3.9 kg of litchi pulp/day for an adult human (weighing 60 kg) and 0.59-1.17 kg of pulp/day for children (1-5 years of age respectively) could be considered a safe quantity.
机译：由于存在低血压植物毒素，低血糖A（HGA）和甲基丁丙基 - 甘氨酸（MCPG），最近据报道，荔枝果实据报道，据据报道，由于存在的低血糖毒素，低血糖A（HGA）和甲基丁丙基 - 甘氨酸（MCPG），与印度的脑病爆发有关。因此，基于动物饲养研究，感觉到需要确定安全的耐受剂量的果实。瑞士白化雌性小鼠（在每组中，n = 6）在饥饿的和未半人的条件下喂食，其中最大可能的荔枝纸浆在10小时内以2.5小时间隔（总量类似于16g）。这不会导致低血糖，减肥或行为变化。血液学曲线，肝脏和肾功能保持不变。脑，肝肾的组织病理学分析也没有表明任何结构变化。从肝脏浆中的上述毒素的报告范围内饲料的量分别对应于2.48的累积最小浓度，并且分别与HGA和MCPG相似的小鼠，其比这些毒素的LD50值小，即90大鼠报道-100mg / kg体重。因此，基于等效剂量转换，约。 3.9千克荔枝纸浆/成年人（体重60千克）和0.59-1.17千克/天儿童（分别为1-5岁），可被视为安全的数量。

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