...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current Science: A Fortnightly Journal of Research >Genomics of Indian SARS-CoV-2: Implications in genetic diversity, possible origin and spread of virus
【24h】

Genomics of Indian SARS-CoV-2: Implications in genetic diversity, possible origin and spread of virus

机译：印度SARS-COV-2的基因组学：遗传多样性的影响，病毒可能的起源和传播

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

World Health Organization (WHO) declared COVID-19 as a pandemic disease on 11 March 2020. Comparison of genome sequences from diverse locations allows us to identify the genetic diversity among viruses which would help in ascertaining viral virulence, disease pathogenicity, origin and spread of the SARS-CoV-2 between countries. The aim of this study is to determine the genetic diversity among Indian SARS-CoV-2 isolates. Initial examination of the phylogenetic data of SARS-CoV-2 genomes (n = 3123) from different continents deposited at GISAID (Global Initiative on Sharing All Influenza Data) revealed multiple origin for Indian isolates. An in-depth analysis of 558 viral genomes derived from samples representing countries from USA, Europe, China, East Asia, South Asia, Oceania, Middle East regions and India revealed that most Indian samples are divided into two clusters. A1 sub-cluster showed more similarity to Oceania and Kuwait samples, while A2 sub-cluster grouped with South Asian samples. In contrast, cluster B grouped with countries from Europe, Middle East and South Asia. Viral clade analysis of Indian samples revealed a high occurrence of G clade (D614G in spike protein; 37%), which is a European clade, followed by I clade (V378I in ORF1ab; 12%), which is an Oceania clade with samples having Iran connections. While A1 cluster is enriched with I clade, the cluster B is enriched with G clade type. Thus our study identifies that the Indian SARS-CoV-2 viruses are enriched with G and I clades in addition to 50% samples with unknown genetic variations. The potential origin to be countries mainly from Europe, Middle East Oceania and South Asia regions, which strongly imply the spread of virus through most travelled countries. The study also emphasizes the importance of pathogen genomics through phylogenetic analysis to discover viral genetic diversity and understand the viral transmission dynamics with eventual grasp on viral virulence and disease pathogenesis.
机译：世界卫生组织（世卫组织）在2020年3月11日宣布Covid-19作为大流行病。各种各样的地区的基因组序列的比较使我们能够识别病毒中的遗传多样性，这有助于确定病毒毒力，疾病致病性，起源和传播。国家之间的SARS-COV-2。本研究的目的是确定印度SARS-COV-2分离株中的遗传多样性。在GISAID沉积的不同大洲的SARS-COV-2基因组（N = 3123）的初步检查SARS-COV-2基因组（n = 3123）（全球共享所有流感数据的倡议）揭示了印度分离株的多个起源。深入分析来自代表美国，欧洲，中国，东亚，南亚，大洋洲，中东地区和印度的各国的样本的558病毒基因组的深入分析显示，大多数印度样本分为两种簇。 A1子集群与大洋洲和科威特样本呈现出更多相似性，而A2子集群与南亚样本进行分组。相比之下，B集团与来自欧洲，中东和南亚的国家分组。印度样本的病毒思潮分析显示出高次数的G伊朗联系。虽然A1集群丰富了I Clade，但群集B富集G型型号。因此，我们的研究确定了印度SARS-COV-2病毒，除了50％的样本外，还富含G和I的遗传变异。主要是来自欧洲，中东大洋洲和南亚地区的国家的潜在来源强烈意味着通过大多数旅行国家的病毒传播。该研究还强调了病原体基因组学通过系统发育分析来发现病毒遗传多样性，并了解易于掌握病毒毒力和疾病发病机制的病毒传动动态。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号