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首页> 外文期刊>Crystal growth & design >The Role of Residence Time Distribution in the Continuous Steady-State Mixed Suspension Mixed Product Removal Crystallization of Glycine
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The Role of Residence Time Distribution in the Continuous Steady-State Mixed Suspension Mixed Product Removal Crystallization of Glycine

机译：停留时间分布在连续稳态混合悬浮液混合产物去除结晶甘氨酸中的作用

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摘要

In this work, a vacuum-driven intermittent transfer technique has been implemented to solve transfer line blockage issues and facilitate steady-state cooling crystallization studies of alpha-glycine in a single- and two-stage mixed suspension mixed product removal (MSMPR) crystallizer. Experimental residence time distribution (RTD) analysis of the stirred tank MSMPR cascade is performed using an imperfect pulse method of the axial dispersion model to benchmark the mixing performance against that of tubular crystallizers and determine the influence of RTD on steady-state size distribution of alpha-glycine product. Process analytical technology (PAT) is used to monitor and understand crystallization process dynamics, and the effect of MSMPR operating temperature, mean residence time, and number of MSMPR stages on mean particle size, crystal size distribution, and yield is studied. Results show the significance of nucleation and growth mechanisms alongside RTD in determining steady-state size distribution, and the need for optimum control of supersaturation to benefit from improved RTDs provided by multistage MSMPR crystallizers.
机译：在这项工作中，已经实施了真空驱动的间歇转移技术，以解决传输线堵塞问题，并促进在单阶段和两级混合悬浮混合产物去除（MSMPR）结晶器中α-甘氨酸的稳态冷却结晶研究。使用轴分散模型的不完美脉冲方法进行搅拌罐MSMPR级联的实验停留时间分布（RTD）分析，以将混合性能与管状结晶器的混合性能进行基准进行，并确定RTD对α的稳态尺寸分布的影响 - 甘氨酸产品。过程分析技术（PAT）用于监测和理解结晶过程动态，研究MSMPR工作温度，平均停留时间和MSMPR阶段的效果，晶体尺寸分布和产量。结果表明核心和生长机制在确定稳态尺寸分布方面的核心和生长机制的意义，以及需要最佳控制超饱和度，从多级MSMPR结晶器提供的改进的RTD中受益。

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  • 来源
    《Crystal growth & design》 |2019年第1期|共15页
  • 作者

    Onyemelukwe Iyke I.; Parsons Anna R.; Wheatcroft Helen P.; Robertson Amy; Nagy Zoltan K.; Rielly Chris D.;

  • 作者单位

    Loughborough Univ Dept Chem Engn EPSRC Ctr Innovat Mfg Continuous Mfg &

    Crystalliz Loughborough LE11 3TU Leics England;

    AstraZeneca Macclesfield PT&

    D Silk Rd Business Pk Charter Way Macclesfield SKI0 2NA Cheshire England;

    AstraZeneca Macclesfield PT&

    D Silk Rd Business Pk Charter Way Macclesfield SKI0 2NA Cheshire England;

    AstraZeneca Macclesfield PT&

    D Silk Rd Business Pk Charter Way Macclesfield SKI0 2NA Cheshire England;

    Loughborough Univ Dept Chem Engn EPSRC Ctr Innovat Mfg Continuous Mfg &

    Crystalliz Loughborough LE11 3TU Leics England;

    Loughborough Univ Dept Chem Engn EPSRC Ctr Innovat Mfg Continuous Mfg &

    Crystalliz Loughborough LE11 3TU Leics England;

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  • 正文语种 eng
  • 中图分类 晶体学;
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