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首页> 外文期刊>Crystal growth & design >Feedback Control for the Size and Shape Evolution of Needle-like Crystals in Suspension. IV. Modeling and Control of Dissolution
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Feedback Control for the Size and Shape Evolution of Needle-like Crystals in Suspension. IV. Modeling and Control of Dissolution

机译：反馈控制悬浮液中针状晶体的尺寸和形状演化。 IV。 溶解的建模与控制

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摘要

Several two-dimensional dissolution rate models for the needle-like compound beta L-glutamic acid (BLGA) in water are obtained by first conducting a series of lab-scale experiments and then applying the maximum likelihood parameter estimation technique within a population balance framework. Among these models, a reasonable choice consists of expressions for the dissolution rates along both particles dimensions that are linear in the driving force and yield a constant value of 12 for the ratio of the dissolution rate along the length of the needles to that along their width. The insights gained from this model are applied to discuss the potential of cyclic processes aimed at modifying the size and the shape of BLGA crystals. Furthermore, a model-free feedback control law with the goal to dissolve a given fraction of the overall solid volume initially suspended in a batch system is presented. This controller is tested in a simulation framework making use of the identified dissolution kinetics. It is also validated experimentally by using BLGA and another compound forming needle-like crystals, vanillin. The results demonstrate its effectiveness and its general applicability, making it suitable for the controlled operation of dissolution stages in cyclic size and shape modification processes.
机译：通过首先进行一系列实验室实验并在群体平衡框架内施加最大似然参数估计技术，获得水中针状化合物β1-谷氨酸（BLGA）的几种二维溶解速率模型。在这些模型中，合理的选择包括沿着驱动力线性的颗粒尺寸的溶出速率的表达式组成，并产生沿着针沿着针的长度的溶出速率与沿其宽度的常数12的恒定值。从该模型中获得的见解用于讨论旨在改变Blga晶体的尺寸和形状的循环过程的可能性。此外，提出了一种与溶解最初悬浮在批量系统中最初悬浮的总固体体积的给定部分的无模型反馈控制定律。该控制器在利用所识别的溶解动力学的仿真框架中进行测试。通过使用BLGA和另一种化合物形成针状晶体，香草蛋白也是通过实验验证的。结果表明其有效性及其一般适用性，适用于循环尺寸和形状改性过程中的溶出阶段的受控操作。

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