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首页> 外文期刊>Crystal growth & design >Reverse Antisolvent Method To Avoid Jelly-like-Phase Generation and Preparation of Crystalline Cefquinome
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Reverse Antisolvent Method To Avoid Jelly-like-Phase Generation and Preparation of Crystalline Cefquinome

机译：逆转抗溶剂方法以避免果冻相似的生成和晶体喹啉的制备

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摘要

In the pharmaceutical industry, crystalline products are preferred because of their higher purity, chemical and physical stability, as well as tunability through crystal engineering. In this study, a crystalline cefquinome (CFQ) product was prepared for the first time. A reverse antisolvent crystallization (RAC) recipe was proposed to avoid the formation of a jelly-like phase (JLP) during the solution crystallization process. A comprehensive characterization and analysis were conducted for the undesirable JLP by using thermogravimetric analysis and rotational rheometry. The results show that the JLP is a semisolid fluid, and it hinders nucleation and growth of crystals. The formation of JLP should be considered as an important factor of lacking crystalline CFQ products in past decades. In this work, the ternary phase diagram was determined to study the mechanism of the RAC process and analyze it for further optimization. The optimized crystallization process was monitored and analyzed by powder X-ray diffraction, in situ Raman spectroscopy, and in situ focused beam reflectance measurement, and produced a higher crystallinity product. In addition, the solubility of the crystalline product and the commercial product was measured in three solvents. The results indicate a higher solubility of the crystalline CFQ product compared to the commercial product which shows great potential for further application.
机译：在制药行业中，结晶产品是优选的，因为它们纯度较高，化学和物理稳定性，以及通过晶体工程的可调性。在该研究中，首次制备了结晶头喹啉（CFQ）产物。提出了反向防溶剂结晶（RAC）配方以避免在溶液结晶过程中形成果冻相相（JLP）。通过使用热重分析和旋转流变测压来对不希望的JLP进行综合表征和分析。结果表明，JLP是半固体液体，其阻碍晶体的成核和生长。 JLP的形成应被视为在过去几十年中缺乏结晶CFQ产品的重要因素。在这项工作中，确定三元相图研究了RAC过程的机制，并分析了进一步优化。通过粉末X射线衍射，原位拉曼光谱法监测和分析优化的结晶过程，并以原位聚焦光束反射率测量，并产生更高的结晶性产品。另外，在三种溶剂中测量结晶产物和商业产品的溶解度。结果表明结晶CFQ产品与商业产品相比的溶解度较高，这表明了进一步应用的巨大潜力。

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  • 来源
    《Crystal growth & design》 |2019年第3期|共8页
  • 作者

    Wang Liping; Zhang Ting; Gao Zhenguo; Bao Ying; Yin Quxiang; Na Ping; Hao Hongxun;

  • 作者单位

    Tianjin Univ Sch Chem Engn &

    Technol Tianjin 300072 Peoples R China;

    Tianjin Univ Sch Chem Engn &

    Technol Tianjin 300072 Peoples R China;

    Tianjin Univ Sch Chem Engn &

    Technol Tianjin 300072 Peoples R China;

    Tianjin Univ Sch Chem Engn &

    Technol Tianjin 300072 Peoples R China;

    Tianjin Univ Sch Chem Engn &

    Technol Tianjin 300072 Peoples R China;

    Tianjin Univ Sch Chem Engn &

    Technol Tianjin 300072 Peoples R China;

    Tianjin Univ Sch Chem Engn &

    Technol Tianjin 300072 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 晶体学;
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