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首页> 外文期刊>Crystal growth & design >Inverse Correlation between Lethality and Thermodynamic Stability of Contact Insecticide Polymorphs
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Inverse Correlation between Lethality and Thermodynamic Stability of Contact Insecticide Polymorphs

机译：接触杀虫剂多晶型物的致死性与热力学稳定性的反比相关性

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Contact insecticides often involve the interaction of whole organisms and toxicant crystal surfaces. The crystalline phase of these compounds has not, however, been considered for the optimization of insecticide performance. Lindane (1R,2r,3S,4R,5r,6S-hexachlorocyclohexane) has been one of the most widely used insecticides, but other (inactive) stereoisomers accompanying its manufacture have led to massive chemical waste remediation problems. Crystalline polymorphs are also isomers in the broadest sense, yet only one crystal structure of lindane has been reported. Herein, we report the discovery and characterization of two new polymorphs, Forms II and III. The efficacy of Forms I, II, and III against Drosophila melanogaster revealed an inverse correlation between lethality and thermodynamic stability; the least stable kills fastest. This understanding provides a crystal engineering opportunity wherein formulations containing the most active contact insecticide polymorph can achieve infectious disease prophylaxis while reducing environmental exposure and associated chemical waste.
机译：接触杀虫剂通常涉及整个生物和毒物晶体表面的相互作用。然而，这些化合物的结晶相未被考虑优化杀虫剂性能。 Lindane（1R，2R，3S，4R，5R，6S-六氯环己烷）是最广泛使用的杀虫剂之一，但伴随其制造的其他（非活性）立体异构体导致了巨大的化学废物修复问题。结晶多晶型物也是最广泛的异构体，但已经报道了林丹的一种晶体结构。在此，我们报告了两种新多晶型物，形式II和III的发现和表征。形式I，II和III对果蝇Melanogaster的疗效揭示了致死率和热力学稳定性之间的反比异性;最不稳定的杀戮最快。该理解提供了一种晶体工程机会，其中含有最活跃的接触杀虫剂多晶型物的制剂可以实现传染病预防，同时减少环境暴露和相关化学废物。

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