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首页> 外文期刊>Crystal growth & design >Compression-Induced Crystallization in Sucrose-Polyvinylpyrrolidone Amorphous Solid Dispersions
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Compression-Induced Crystallization in Sucrose-Polyvinylpyrrolidone Amorphous Solid Dispersions

机译：蔗糖 - 聚乙烯吡咯烷酮无定形固体分散体的压缩诱导的结晶

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摘要

Tablets of amorphous sucrose and sucrose-polyvinylpyrrolidone (PVP) amorphous solid dispersions were compressed at 25, 75, or 150 MPa at dwell times ranging from 5 to 900 s. Compression-induced physical destabilization was evident from differential scanning calorimetry. Crystallization kinetics was monitored using a laboratory source X-ray diffractometer, while crystallization was detected using highly sensitive synchrotron radiation. At the highest compression pressure, sucrose crystallization was evident immediately after compression. However, the addition of PVP, even at a low concentration of 1% w/w, inhibited crystallization. Furthermore, nucleation itself was completely prevented at higher PVP concentrations (≥15% w/w) under a compression pressure of practical interest (150 MPa with 5 s dwell time). However, an increase in dwell time (e.g., to 60 s) facilitated nucleation, and there was an increase in nucleation density as a function of dwell time. Both polymer content and sample history were pivotal factors limiting compression-induced crystallization in plasticized amorphous systems. Generally, plasticization was found to amplify compression-induced destabilization. PVP, in a concentration dependent manner, attenuated this effect.
机译：无定形蔗糖和蔗糖 - 聚乙烯吡咯烷酮（PVP）无定形固体分散体在25,75或150MPa下在5-900秒的停留时压缩。从差示扫描量热法术明显明显压缩诱导的物理稳定化。使用实验室源X射线衍射仪监测结晶动力学，同时使用高敏感的同步辐射检测结晶。在最高的压缩压力下，压缩后立即明显明显。然而，加入PVP，甚至低于1％w / w的低浓度，抑制结晶。此外，在实际兴趣的压缩压力下，在更高的PVP浓度（≥15％w / w）下完全预防成核本身（150mPa，5秒停留时间）。然而，停留时间（例如，至60秒）的增加促进成核，并且核切割密度随着停留时间的函数而增加。聚合物含量和样本历史均为限制塑化非晶系统中的压缩诱导的结晶的枢转因子。通常，发现塑化扩增压缩诱导的稳定稳定化。 PVP以浓度依赖方式，减弱了这种效果。

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  • 来源
    《Crystal growth & design》 |2018年第2期|共10页
  • 作者

    Ka?rlis Be?rzi??; Raj Suryanarayanan;

  • 作者单位

    Latvian Institute of Organic Synthesis Aizkraukles iela 21 LV-1006 Riga Latvia;

    Department of Pharmaceutics College of Pharmacy University of Minnesota 308 Harvard Street S.E. Minneapolis Minnesota 55455 United States;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 晶体学;
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