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首页> 外文期刊>ACS applied materials & interfaces >Lentinan-Functionalized Graphene Oxide Is an Effective Antigen Delivery System That Modulates Innate Immunity and Improves Adaptive Immunity
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Lentinan-Functionalized Graphene Oxide Is an Effective Antigen Delivery System That Modulates Innate Immunity and Improves Adaptive Immunity

机译：十一醛官能化的石墨烯氧化物是一种有效的抗原递送系统，可调节先天免疫力并提高自适应免疫力

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摘要

Graphene oxide (GO) and lentinan have received great attention because of their utility in biomedical applications. Graphene oxide is utilized in drug- and vaccine-delivery systems due to its biocompatibility, large surface area, and outstanding adsorption capability, while lentinan has immunity-enhancing effects. In this study, we synthesized and characterized GO grafted with lentinan (LNT) as an adjuvant and investigated how to impact the immune responses. Lentinan-modified GO (GO-LNT) facilitated antigen uptake in macrophages and improved the efficiency of antigen application in vitro. Furthermore, in vivo, compared with GO/OVA, GO-LNT/OVA decreased the release rate of ovalbumin (OVA) to sustain long-term immune responses and boost the levels of IgG and IgG subtypes. Hence, we can infer that the effects of GO-LNT were a result of the increased amounts of antigen uptake by cells. Overall, our studies demonstrated that GO-LNT could suffice for a safe and effective vaccine-delivery system as well as an excellent adjuvant that both elicits a long-term immune memory response and potentiates cellular and humoral immunity.
机译：由于其在生物医学应用中的效用，石墨烯氧化物（GO）和Lentinan非常重视。由于其生物相容性，大表面积和出色的吸附能力，石墨烯氧化物用于药物和疫苗输送系统，而Lentinan具有免疫增强作用。在这项研究中，我们合成并表征与月桂醛（LNT）接枝作为佐剂，并研究了如何影响免疫反应。 Lentinan改性的Go（Go-LNT）促进巨噬细胞的抗原摄取，提高了体外抗原施用的效率。此外，在体内，与Go / OVA相比，Go-LNT / OVA减少了卵烧蛋白（OVA）的释放速率，以维持长期免疫应答并促进IgG和IgG亚型的水平。因此，我们可以推断Go-LNT的影响是细胞增加抗原吸收量增加的结果。总体而言，我们的研究表明，Go-LNT可以满足安全有效的疫苗输送系统以及优异的佐剂，即均以长期免疫记忆响应和增强细胞和体液免疫引起的佐剂。

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