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首页> 外文期刊>ACS applied materials & interfaces >Peptide-Decorated Ultrasmall Superparamagnetic Nanoparticles as Active Targeting MRI Contrast Agents for Ovarian Tumors
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Peptide-Decorated Ultrasmall Superparamagnetic Nanoparticles as Active Targeting MRI Contrast Agents for Ovarian Tumors

机译：肽装饰的超分子磁性纳米粒子作为卵巢肿瘤的活性靶向MRI造影剂

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摘要

Magnetic resonance imaging (MRI) is widely applied in medical research and diagnosis, and a MRI contrast medium plays a crucial role in improving the sensitivity of detection. Ultrasmall superparamagnetic iron oxides (USPIOs) exhibit the potential as a T _(2) enhancement contrast medium for MRI due to their excellent magnetic response performance; however, to endow them with specific tumor targetability, long-term circulation performance has always been a hot topic in this field. In this study, a well-designed procedure of chemical coprecipitation, surface modification, and peptide grafting was applied to prepare the active tumor-targeting [email?protected], in which Pluronic F127 (F127) and the peptide WSGPGVWGASVK (peptide-WSG) were selected as the template agent and the ovarian tumor-targeting ligand, respectively. The results showed that single [email?protected] particles were Fe_(3)O_(4) nanoparticles regulated by the confinement effect of F127 micelles with a uniform globular morphology and size (～9 nm), and peptide-WSG was grafted for their tumor targetability. [email?protected] particles presented superparamagnetic behavior with high T _(2) relaxivity (r _(2) = 278.15 mM~(–1) s~(–1)) and in vitro targetability for SKOV-3 cells due to the special binding between peptide-WSG and specific receptors of SKOV-3. The test results in vivo verified the targetability of [email?protected] by their specific aggregation in the tumor regions, leading to the T _(2)-weighted MRI contrast enhancement. These outstanding properties indicate that [email?protected] have great potential to be applied as the active tumor-targeting contrast agent for MRI.
机译：磁共振成像（MRI）广泛应用于医学研究和诊断，MRI造影剂在提高检测灵敏度方面发挥着至关重要的作用。超级连锁铁氧化铁（USPIOS）由于其优异的磁响应性能而表现为MRI的潜在增强造影介质;然而，为了赋予它们特异性的肿瘤靶向性，长期循环性能一直是该领域的热门话题。在该研究中，施用了精心设计的化学共沉淀，表面改性和肽接枝的程序，以制备活性肿瘤靶向[电子邮件吗？受保护的]，其中Pluronic F127（F127）和肽WSGPGVWGASVK（肽-WSG）分别被选择为模板剂和卵巢肿瘤靶向配体。结果表明，单一[邮箱吗？受保护的]颗粒是通过F127胶束的限制效果调节Fe_（3）O_（4）纳米颗粒，其具有均匀的球状形态和尺寸（〜9nm），并且肽-WSG接枝它们肿瘤靶向性。 [电子邮件吗？受保护的]粒子呈现出高度降光的行为，高 T_（2）放松率（ r _（2）= 278.15mm〜（-1）S〜（-1））和Skov的体外靶向性-3细胞由于肽-WSG与Skov-3的特异性受体之间的特殊结合。体内测试结果验证了肿瘤区域中的[电子邮件？保护]的靶向性，导致 T_（2） - 重量的MRI对比度增强。这些出色的属性表明[邮箱吗？受保护的]具有巨大的潜力，可用作MRI的活性肿瘤靶向造影剂。

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